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Relationbetween201TlReverseRedistributionandEndothelialDysfunctioninPatientswithCoron...
Relation between 201Tl Reverse Redistribution and Endothelial Dysfunction in Patients with Coronary Artery Spasm
Abstract
Research background: Coronary artery spasm (CAS) is a group of common clinic syndromes with the main represent as resting chest pain and ECG transient ST-elevation attending with. CAS is not only the main mechanism for variant angina pectoris, but also one of the important pathophysiology basis for many ischemia heart diseases including unstable angina pectoris, acute myocardial infarction and sudden cardiac death, with the mechanism is not clear, and might be related to the coronary artery spasm, vascular smooth muscle vasomotor function abnormality as well as autonomic nervous function unbalance. At present, the diagnosis for CAS mainly depends on coronary provocative tests including acetylcholine test and methysergide test. The domestic scholars found that reverse redistribution (RR) showed in 201Tl SPECT myocardial perfusion imaging heart burden test was one of the characters in CAS patients, if combining the clinic characters of negative ECG exercise and resting chest pain, the sensitivity and the specificity for CAS diagnosis could reach to 98% and 90%, respectively. However, the clinic significance of reverse redistribution is in dispute at present, this paper aimed at through comparing the change of plasma ET-1, NO contents as well as ET-1/NO level before and after myocardial perfusion imaging burden test on patients to further investigate the relations between RR and endothelial dysfunction. 展开
Abstract
Research background: Coronary artery spasm (CAS) is a group of common clinic syndromes with the main represent as resting chest pain and ECG transient ST-elevation attending with. CAS is not only the main mechanism for variant angina pectoris, but also one of the important pathophysiology basis for many ischemia heart diseases including unstable angina pectoris, acute myocardial infarction and sudden cardiac death, with the mechanism is not clear, and might be related to the coronary artery spasm, vascular smooth muscle vasomotor function abnormality as well as autonomic nervous function unbalance. At present, the diagnosis for CAS mainly depends on coronary provocative tests including acetylcholine test and methysergide test. The domestic scholars found that reverse redistribution (RR) showed in 201Tl SPECT myocardial perfusion imaging heart burden test was one of the characters in CAS patients, if combining the clinic characters of negative ECG exercise and resting chest pain, the sensitivity and the specificity for CAS diagnosis could reach to 98% and 90%, respectively. However, the clinic significance of reverse redistribution is in dispute at present, this paper aimed at through comparing the change of plasma ET-1, NO contents as well as ET-1/NO level before and after myocardial perfusion imaging burden test on patients to further investigate the relations between RR and endothelial dysfunction. 展开
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研究背景:冠状动脉痉挛(CAS)是一群普通门诊综合征的主要表现为与胸痛和心电图短暂休息和st段抬高性出席。CAS不仅是主要的机制,而且心绞痛变种的一个重要的病理生理学基础心脏疾病,包括许多缺血的不稳定性心绞痛、急性心肌梗塞和猝死,与机制尚不清楚,也许是冠状动脉痉挛有关,血管平滑肌毛细血管收缩功能异常以及自主神经功能不平衡。目前,诊断为CAS主要依赖冠脉挑衅的试验测试和methysergide测试包括乙酰胆碱。国内学者发现,扭转(RR)分配在201Tl SPECT心肌灌注显像心脏负担试验中的人物之一,如果结合CAS病人的临床特点和休息的负面的心电图胸痛、运动的敏感性和特异性,可达98% CAS诊断和90%。然而,临床意义的分配是争议扭转目前,本文旨在通过对比变化,没有内容的等离子体ET-1以及ET-1 /无级之前和之后的心肌灌注显像负担进一步研究试验的患者之间的关系,与内皮功能障碍。
研究背景:冠状动脉痉挛(CAS)是一群普通门诊综合征的主要表现为与胸痛和心电图短暂休息和st段抬高性出席。CAS不仅是主要的机制,而且心绞痛变种的一个重要的病理生理学基础心脏疾病,包括许多缺血的不稳定性心绞痛、急性心肌梗塞和猝死,与机制尚不清楚,也许是冠状动脉痉挛有关,血管平滑肌毛细血管收缩功能异常以及自主神经功能不平衡。目前,诊断为CAS主要依赖冠脉挑衅的试验测试和methysergide测试包括乙酰胆碱。国内学者发现,扭转(RR)分配在201Tl SPECT心肌灌注显像心脏负担试验中的人物之一,如果结合CAS病人的临床特点和休息的负面的心电图胸痛、运动的敏感性和特异性,可达98% CAS诊断和90%。然而,临床意义的分配是争议扭转目前,本文旨在通过对比变化,没有内容的等离子体ET-1以及ET-1 /无级之前和之后的心肌灌注显像负担进一步研究试验的患者之间的关系,与内皮功能障碍。
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