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significantly higher than those in the normal control group (P<0.01). When the three indicators were tested separately, the serum indicator with the highest specificity for the diagnosis of PHC was AST (100%), and the one with the highest sensitivity was AFP (95%). The indicator with the highest positive predictive value and negative predictive value were AST (100%) and AFP (94.05%), respectively. The sensitivity (100%) and negative predictive value (100%) of combined detection for diagnosing PHC were significantly higher than those of single detection. Conclusion: AFP, ALT, and AST have significant clinical value in the diagnosis of primary hepatic carcinoma, and the efficiency of combined detection is better than that of single detection.
咨询记录 · 回答于2023-04-08
论文摘要英文翻译
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原发性肝癌患者血清学指标的临床价值调查报告摘要目的 调查并报告甲胎蛋白(alpha fetoprotein, AFP)、丙氨酸氨基转移酶(alanine transaminase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)等血清学指标在原发性肝癌(primary hepatic carcinoma,PHC)诊断中的临床价值。方法 收集2020年至2022年在西藏自治区人民医院诊断为原发性肝癌的100个患者为研究组,在这时间范围内的80个健康体检者为对照组,然后对AFP、ALT、AST三个指标检测结果的数据进行回顾性分析;AFP通过化学发光检测,ALT、AST 浓度采用速率法检测,通过调查受试者病例基本信息,总结原发性肝癌在性别、年龄上的特点;通过调查AFP、ALT、AST 浓度异常率,比较在研究组和对照组中各个标志物的检测结果差异,并计算其差异是否具有统计学意义;运用spss软件进行统计学分析,计算各个指标单独及联合检测的灵敏度、特异度、阳性预测值、阴性预测值,并绘制ROC曲线来报告和评价各个指标对肝癌的诊断效率和临床价值。
整体是这样
Clinical Value Investigation on Serum Markers for Primary Hepatic Carcinoma Patients: A ReportAbstractObjective: To investigate and report the clinical value of serum markers such as alpha fetoprotein (AFP), alanine transaminase (ALT), and aspartate aminotransferase (AST) in the diagnosis of primary hepatic carcinoma (PHC). Methods: A retrospective analysis was conducted on 100 patients diagnosed with PHC at the People's Hospital of Tibet Autonomous Region between 2020 and 2022, who were selected as the study group. Eighty healthy individuals who underwent physical examinations during the same period were selected as the control group. The data of AFP, ALT, and AST were detected by chemiluminescence and rate method, respectively. The characteristics of PHC in terms of gender and age were summarized by investigating the basic information of the subjects. By investigating the abnormal rate of AFP, ALT, and AST concentrations, the difference in the detection results of each marker bet
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Objective: To investigate and report the clinical value of serum indicators, such as alpha fetoprotein (AFP), alanine transaminase (ALT), and aspartate aminotransferase (AST), in the diagnosis of primary hepatic carcinoma (PHC). Methods: 100 patients diagnosed with PHC at the People's Hospital of Tibet Autonomous Region from 2020 to 2022 were selected as the study group, while 80 healthy examinees during the same period were selected as the control group. The data of AFP, ALT, and AST were collected and analyzed retrospectively. The concentrations of AFP were detected by chemiluminescence assay, while the concentrations of ALT and AST were detected by the rate method. The basic information of the cases was investigated to summarize the characteristics of PHC in terms of gender and age.
The abnormal rates of AFP, ALT, and AST were investigated, and the differences in the detection results of various markers between the study and control groups were compared. Statistical analysis was performed using SPSS software to calculate the sensitivity, specificity, positive predictive value, and negative predictive value of each index alone and in combination. ROC curves were drawn to report and evaluate the diagnostic efficiency and clinical value of each index for liver cancer. Results: The results of the three indicators in the primary hepatic carcinoma group were
significantly higher than those in the normal control group (P<0.01). When the three indicators were tested separately, the serum indicator with the highest specificity for the diagnosis of PHC was AST (100%), and the one with the highest sensitivity was AFP (95%). The indicator with the highest positive predictive value and negative predictive value were AST (100%) and AFP (94.05%), respectively. The sensitivity (100%) and negative predictive value (100%) of combined detection for diagnosing PHC were significantly higher than those of single detection. Conclusion: AFP, ALT, and AST have significant clinical value in the diagnosis of primary hepatic carcinoma, and the efficiency of combined detection is better than that of single detection.
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