Question

邻苯二甲酸酐的物质毒性

Answer 1

编号 毒性类型 测试方法 测试对象 使用剂量 毒性作用 1 acute Oral Rodent - rat 1530 mg/kg 1.行为毒性Behavioral - somnolence (general depressed activity) 2 acute Inhalation Rodent - rat >210 mg/m3/1H 1.Details of toxic effects not reported other than lethal dose value 3 acute Oral Rodent - mouse 1500 mg/kg 1.Details of toxic effects not reported other than lethal dose value 4 acute Oral Mammal - cat 800 mg/kg 1.Details of toxic effects not reported other than lethal dose value 5 acute Administration onto the skin Rodent - rabbit >10 mg/kg 1.Details of toxic effects not reported other than lethal dose value 6 acute Intraperitoneal Rodent - guinea pig 100 mg/kg 1.Details of toxic effects not reported other than lethal dose value 7 MutipleDose Inhalation Rodent - rat 100 mg/m3/2H/2W-I 1.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi　　2.肝毒性Liver - other changes 8 MutipleDose Oral Rodent - guinea pig 6 mg/kg/42D-I 1.肺部、胸部或者呼吸毒性Lungs, Thorax, or Respiration - other changes　　2.胃肠道毒性Gastrointestinal - gastritis　　3.胃肠道毒性Gastrointestinal - other changes 9 SkinEyeIrrition Administration onto the skin Rodent - rabbit 500 mg/24H 1.Mild 10 SkinEyeIrrition Administration into the eye Rodent - rabbit 50 mg/24H/MOD 　11 Mutation 　Rodent - rat Liver 3 mmol/L 　12 Reproductive Inhalation Rodent - rat 1 mg/m3,male 45 day(s) pre-mating 1.生殖毒性Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)　　2.生殖毒性Reproductive - Paternal Effects - testes, epididymis, sperm duct 13 Reproductive Intraperitoneal Rodent - mouse 203 mg/kg,female 8-10 day(s) after conception 1.生殖毒性Reproductive - Specific Developmental Abnormalities - other developmental abnormalities