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想要表达某人怎么了可以说成what's the matter with + 人（用人称代词的宾格）。也可以用what's the trouble with+人。还可以用what's wrong with+人。
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What's wrong with you?
=What's the matter(with you)?
意思是：你怎么啦？
What's wrong with him?
或者：What's the matter with him?
他怎么啦？
=What's the matter(with you)?
意思是：你怎么啦？
What's wrong with him?
或者：What's the matter with him?
他怎么啦？
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be the matter with sb是固定搭配
所以你可以套用这个句型
What's the matter with you? 你怎么啦？
What's the matter with him? 他怎么啦？
所以你可以套用这个句型
What's the matter with you? 你怎么啦？
What's the matter with him? 他怎么啦？
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What's wrong with you? 你怎么了
What's the matter with him? 他怎么了？
What's the matter with him? 他怎么了？
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What's the matter with you?
What's the matter with him?
What's the matter with him?
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