Question

take care of与take care有什么区别？

Answer 1

take care单独使用，后面不需要接成分

Answer 2

take care of 照顾, 照料 of后面要加相应的宾语成份。
He's old enough to take care of himself.
他大了，能照顾自己了。
take care 当心, 注意
Take care (that) you don't drink too much/not to drink too much.
当心别喝多了。
He is in a bad temper this morning; take care not to step on his toes.
他今天上午心情不好，当心一点，不要触犯他。