Question

什么是variant allele fraction（VAF）？

生物学达人请解释一下：这个名词的中文是什么？含义是什么？在文献中看到“
The majority of the identified variants in
each AML sample formed a variant cluster with a variant allele
fraction (VAF) of 45%–50%, which corresponds to heterozygous
somatic mutations present in nearly all cells in the sample; this
variant cluster marks the founding clone, from which all leukemic
cells descend.”这样的描述，不明白VAF无法往下看啊！对点化我的达人不胜感激！

Answer 1

你好
中文是：等位基因变体分数
应该是等位基因中变体占的百分数！
希望能帮到你！