Question

乳腺浸润性导管癌 免疫组化ER(3+)，PR(3+)，Her-2(-), P63、CK5/6显示导管肌上皮细胞缺失，Ki67标记指数9%

免疫组化ER(3+)，PR(3+)，Her-2(-), P63、CK5/6显示导管肌上皮细胞缺失，Ki67标记指数9%。乳腺活检标本）灰白肿物一个，体积：2.5cmx2cmx1cm,部分包膜，切面灰白灰黄。
光镜所见：乳腺异型细胞呈腺管状排列，部分呈筛孔状，细胞核为圆形，排列拥挤。
病理诊断：乳腺浸润性导管癌（WHO I级，5分）

以上情况严重吗？以后最好如何治疗？

Answer 1

ER是雌激素受体，PR是孕激素受体，两者与内分泌治疗密切相关。Her-2癌基因的过度表达是乳腺癌患者预后差的指证。ER、PR阳性，Her-2阴性的患者进行三苯氧胺治疗可取得良好的效果。而三者同时阳性的患者，采用三苯氧胺治疗并无意义，甚至更差。相反Her-2的高表达，以及KI67的增殖指数越高，表明肿瘤的恶性程度越高，预后越差。从上面指标的表达来看应该比较乐观，应到肿瘤科积极治疗，当然，最终影响疗效的原因是多方面的，如：个人体质、对药物敏感度、肿瘤的范围等等，最重要的还是心态，这一点尤为重要。

Answer 2

没有介绍淋巴结转移情况，根据目前资料看情况不算严重。ER,PR都是强阳性，说明对内分泌治疗比较敏感，效果会比较好。病理级别也较低，Her-2还是阴性。说明恶性程度低。应积极配合治疗。完善化疗和内分泌治疗，会有良好的预后。

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Answer 4

乳腺癌的主要症状表现为：乳腺肿块、乳腺疼痛、乳头溢液、乳头改变、皮肤改变、腋窝淋巴结肿大。
乳腺癌特效验方“孔氏乳癌散瘀汤”能够真正达到减少痛苦、减轻症状、提高生存质量、有效抑制复发和转移、延长生命的目的。使乳腺癌治疗走向科学化、规范化、专业化，实现了肺癌治疗的整体、针对性和有效性。孔教授根据“孔氏乳癌散瘀汤”药理药性及多年乳腺癌治疗经验，首创清肿块抑癌疗法，是乳腺癌治疗史上的重大突破，是迄今为止乳腺癌医学领域最新的科学治疗方法之一，为乳腺癌医学领域提供了一整套切实可行、行之有效的治疗方案，为提高中医在肿瘤治疗领域的地位和声誉作出重大贡献。