Question

求英语翻译,急求~~~~~

Interestingly,Azone and derivatives are effective penetration cnhancers when used in (1—5%. Their activity can be increased by the addition of cosolvents like propylene glycol or cthanol.Azone derivatives are soluble in these liquids and compatible with most organic solvents,and these are other advantages of this type of artificial enhancers.
Although Azone and its derivatives have now been in use as penctration cnhancers for over 20 years,their mechanism of action is under ongoing research. The penetration-enhancing effects of these compounds are probably due to an intercalation into the structured lipids of the stratum corneum and the disturbance of the lipid packing order. The carbon chain of the Azone molecule consists of 12 carbon atoms. The dimensions of this chain are comparable with the dimensions of the cholesterolskeleton. A decrdase in the cholesterol-cholesterol interferences and the cholesterol-ceramide interactions can beassumed in the presence of Azone derivatives. The fluidity of the hydrophobic stratum corneum regions is increased and the permeation resistance of the horny layeragainst drug substances is reduced by Azone.
Among the large number of investigated Azone derivatives,the compounds with a chain lcngth of 12 carbon atoms were the most effective ones independent of the ring dimensions.

Answer 1

绝对原创，全部手打，花了好长时间，你给的文章有好多错单词，下面附有修正后的原文。不给我分你就瞎了。
有趣的是，1-5％的氮酮及其衍生物是有效的渗透促进剂。他们的活性可以像丙二醇或者乙醇一样通过增加夹带剂来提高。氮酮衍生物可以溶解于这些溶液并且易溶于大多数有机溶剂，这是它们这类人工促进剂的更一个优点。
虽然氮酮及其衍生物至今已经作为渗透促进剂使用超过了20年，但是它们作用的机理还是正在研究当中。促进这些化合物溶解的作用可能是因为它们会插入角质层中被构建的血脂并且干扰那些血脂的排列。氮酮分子的碳链由12个碳原子组成。这个链条的大小与胆固醇骨架链条的大小一样。由于胆固醇干扰的减少，可以相像得到在氮酮衍生物中会发生胆固醇神经酰胺的反应。疏水性角质层区域的流动性增加，并且氮酮会使药物渗透进角质层的阻力减小。
在大量的对氮酮衍生物在研究中发现，链长为12个碳原子的化合物是最有效的独立环大小。
Interestingly, Azone and derivatives are effective penetration enhancers when used in 1—5%. Their activity can be increased by the addition of cosolvents like propylene glycol or ethanol. Azone derivatives are soluble in these liquids and compatible with most organic solvents, and these are other advantages of this type of artificial enhancers.
Although Azone and its derivatives have now been in use as penetration enhancers for over 20 years, their mechanism of action is under ongoing research. The penetration-enhancing effects of these compounds are probably due to an intercalation into the structured lipids of the stratum corneum and the disturbance of the lipid packing order. The carbon chain of the Azone molecule consists of 12 carbon atoms. The dimensions of this chain are comparable with the dimensions of the cholesterol-skeleton. A decrease in the cholesterol-cholesterol (这里我不看明白为什么是两个重复的)interferences and the cholesterol-ceramide interactions can be assumed in the presence of Azone derivatives. The fluidity of the hydrophobic stratum corneum regions is increased and the permeation resistance of the horny layer against drug substances is reduced by Azone.
Among the large number of investigated Azone derivatives, the compounds with a chain length of 12 carbon atoms were the most effective ones independent of the ring dimensions.

Answer 2

有趣的是，氮酮及其衍生物是有效的渗透使用时（1-5％。它们的活动可以由像丙二醇或cthanol.Azone夹带剂的加入提高cnhancers衍生物是这些液体易溶于大多数有机溶剂和兼容，而这些是这种人为的增强型等优点。
氮酮及其衍生物，虽然现在已经作为penctration cnhancers使用超过20年以来，其作用机制是在正在进行的研究。这些化合物的渗透增强效应可能是由于进入角质层脂质的结构化夹层和脂质包装秩序的干扰。氮酮分子的碳链组成的12个碳原子。这个链条的尺寸与cholesterolskeleton的尺寸相媲美。中的胆固醇，胆固醇的干扰和胆固醇酰胺相互作用decrdase可以beassumed氮酮衍生物的存在。疏水性角质层地区流动性增加，药物的角质layeragainst物质渗透阻力是由氮酮降低。
其中氮酮衍生物的大量调查，与12个碳原子链lcngth化合物是最有效的独立的戒指尺寸.

Answer 3

有趣的是,Azone及衍生工具是有效的渗透cnhancers用于(1-5%。可以提高他们的活动被加上了cosolvents像丙二醇或cthanol . Azone衍生品都是溶于这些液体和兼容绝大多数有机溶剂,这是这种类型的其他优点人工的错误。
虽然Azone及其衍生物已经被使用作为元素的超过20年,cnhancers的作用机制,在目前的研究。这些化合物的penetration-enhancing的影响可能是由于一种夹层结构的脂质的角质层及干扰的脂类包装秩序。碳链的分子Azone碳原子由12。这链子的规模基本已与cholesterolskeleton的尺寸。一个decrdase在cholesterol-cholesterol干扰的相互作用的cholesterol-ceramide面前beassumed Azone衍生品。疏水的流动性,增加角质层地区渗透角质层的抗layeragainst原料药降低Azone。
在大量调查Azone衍生物用一条链子,这些物质lcngth 12个碳原子的最有效的独立的戒指尺寸。 ok!

Answer 4

有趣的是，氮酮及其衍生物是有效的渗透使用时（1-5％。它们的活动可以由像丙二醇或cthanol.Azone夹带剂的加入提高cnhancers衍生物是这些液体易溶于大多数有机溶剂和兼容，而这些其他优点是人工促进剂的这种类型。氮酮及其衍生物，虽然现在年已penctration在使用中cnhancers超过20，其作用机制的研究正在继续进行。促进作用，这些化合物的渗透，都可能是由于插层到角质层的结构化脂质和脂质包装秩序紊乱。氮酮的分子的碳链由12个碳原子组成。这项链的尺寸与cholesterolskeleton的尺寸可比。decrdase中的胆固醇胆固醇的干扰和胆固醇在神经酰胺相互作用可以beassumed氮酮衍生物的存在。的地区流动性的疏水角质层增加，药物性物质渗透的角质layeragainst是氮酮降低。在被调查的大量氮酮衍生物，具有12个碳原子链lcngth化合物是最有效的环尺寸无关。