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题目：丹红注射液对不稳定型心绞痛患者血管内皮功能及炎症因子的影响
作者单位：南京中医药大学临床医学院
摘要 目的：旨在探讨丹红注射液对不稳定型心绞痛(UAP)患者血管内皮功能相关因子、炎症因子水平的影响。方法：72例UAP患者按1:1原则随机分为治疗组(丹红组)36例和对照组（常规组）36例，对照组给予常规药物治疗；治疗组在常规药物基础上给予丹红注射液治疗（丹红注射液30ml+生理盐水250ml，ivgtt，qd），疗程为两周。检测治疗前后血清内皮素-1（ET-1）、一氧化氮（NO）、超敏C反应蛋白（hs-CRP）、纤维蛋白原（Fg）、肿瘤坏死因子-α(TNF-α)水平的变化。结果：治疗前两组患者血清ET-1、hs-CRP、Fg及TNF-α水平均有明显升高，血清NO水平则均有明显下降，治疗后治疗组血清ET-1、hs-CRP、Fg及TNF-α水平较对照组下降更为显著（P＜0.05），血清NO水平则较对照组升高更为显著（P＜0.05）。结论：丹红注射液可有效降低UAP患者血清ET-1、hs-CRP、Fg及TNF-α水平水平，升高血清NO水平，具有抑制炎症反应、改善血管内皮功能的良好作用。
关键词 丹红注射液 不稳定型心绞痛 血管内皮功能 炎症因子
表-1 两组患者治疗前后血清ET-1、NO水平比较（ ±S）
注：丹红组治疗前后比较，★P<0.01；常规组治疗前后比较，◇P<0.05；两组治疗后比较，▲ P<0.05。
表-2 两组患者治疗前后血清hs-CRP、Fg及TNF-α水平比较（ ±S）
注：丹红组治疗前后比较，△P<0.01；常规组治疗前后比较，◆P<0.05；两组治疗后比较，☆ P<0.05。

Answer 1

Topic: Dan red injection of unstable angina patients with vascular endothelial function and influence of inflammatory markers
The author units: nanjing university of traditional Chinese medicine clinical medical school
Objective: to explore Dan red injection to unstable angina (UAP) patients with vascular endothelial dysfunction related factors, inflammatory factor leels influence. Methods: 72 cases according to the principle of 1:1 UAP patients were randomly divided into the treatment group (Dan red group) and control group (36 cases of conventional group) 36 cases and control; to conventional treatments. In treatment group based on conventional drugs to Dan red injection therapy (Dan red injection 30ml + physiological saline, 250ml ivgtt, qd), treatment for two weeks. Test before and after the treatment of serum endothelin - 1 (ET - 1), nitric oxide (NO), allergic c-reactive protein (hs) - the fibrinogen CRP), (Fg), tumor necrosis factor (TNF alpha (alpha) level changes. Results: treatment before two groups patients serum ET - 1, hs - CRP, Fg and TNF alpha levels were significantly increased, serum level is aubject are obviously decreased, the treatment group serum ET - 1, hs - CRP, Fg and TNF alpha level is more significant decline control group (P < 0.05), serum level was elevated aubject to control more significant (P < 0.05). Conclusion: Dan red injection can effectively reduce the UAP patients serum ET - 1, hs - CRP, Fg and TNF alpha level level, increase serum aubject level, can inhibit inflammation, improves endothelial function of good effect.
Keywords Dan red injection unstable angina endothelial function of proinflammatory factor
Table - 1 two groups of patients before and after the treatment of serum ET - 1, NO level is (+ S)
Note: Dan red group compared before and after treatment, P < 0.01; u Conventional group compared before and after treatment, P < 0.05); so The two groups after treating comparison, ▲ P < 0.05.
Table 2-2 groups before and after the treatment of serum hs - CRP, Fg and TNF alpha level is (+ S)
Note: Dan red treatment group before-and-after, enables delta P < 0.01, Conventional treatment group before-and-after, a P < 0.05, The two groups after treating comparison, ☆ P < 0.05.

Answer 2

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