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题目:丹红注射液对不稳定型心绞痛患者血管内皮功能及炎症因子的影响作者单位:南京中医药大学临床医学院摘要目的:旨在探讨丹红注射液对不稳定型心绞痛(UAP)患者血管内皮功能相...
题目:丹红注射液对不稳定型心绞痛患者血管内皮功能及炎症因子的影响
作者单位:南京中医药大学临床医学院
摘要 目的:旨在探讨丹红注射液对不稳定型心绞痛(UAP)患者血管内皮功能相关因子、炎症因子水平的影响。方法:72例UAP患者按1:1原则随机分为治疗组(丹红组)36例和对照组(常规组)36例,对照组给予常规药物治疗;治疗组在常规药物基础上给予丹红注射液治疗(丹红注射液30ml+生理盐水250ml,ivgtt,qd),疗程为两周。检测治疗前后血清内皮素-1(ET-1)、一氧化氮(NO)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fg)、肿瘤坏死因子-α(TNF-α)水平的变化。结果:治疗前两组患者血清ET-1、hs-CRP、Fg及TNF-α水平均有明显升高,血清NO水平则均有明显下降,治疗后治疗组血清ET-1、hs-CRP、Fg及TNF-α水平较对照组下降更为显著(P<0.05),血清NO水平则较对照组升高更为显著(P<0.05)。结论:丹红注射液可有效降低UAP患者血清ET-1、hs-CRP、Fg及TNF-α水平水平,升高血清NO水平,具有抑制炎症反应、改善血管内皮功能的良好作用。
关键词 丹红注射液 不稳定型心绞痛 血管内皮功能 炎症因子
表-1 两组患者治疗前后血清ET-1、NO水平比较( ±S)
注:丹红组治疗前后比较,★P<0.01;常规组治疗前后比较,◇P<0.05;两组治疗后比较,▲ P<0.05。
表-2 两组患者治疗前后血清hs-CRP、Fg及TNF-α水平比较( ±S)
注:丹红组治疗前后比较,△P<0.01;常规组治疗前后比较,◆P<0.05;两组治疗后比较,☆ P<0.05。 展开
作者单位:南京中医药大学临床医学院
摘要 目的:旨在探讨丹红注射液对不稳定型心绞痛(UAP)患者血管内皮功能相关因子、炎症因子水平的影响。方法:72例UAP患者按1:1原则随机分为治疗组(丹红组)36例和对照组(常规组)36例,对照组给予常规药物治疗;治疗组在常规药物基础上给予丹红注射液治疗(丹红注射液30ml+生理盐水250ml,ivgtt,qd),疗程为两周。检测治疗前后血清内皮素-1(ET-1)、一氧化氮(NO)、超敏C反应蛋白(hs-CRP)、纤维蛋白原(Fg)、肿瘤坏死因子-α(TNF-α)水平的变化。结果:治疗前两组患者血清ET-1、hs-CRP、Fg及TNF-α水平均有明显升高,血清NO水平则均有明显下降,治疗后治疗组血清ET-1、hs-CRP、Fg及TNF-α水平较对照组下降更为显著(P<0.05),血清NO水平则较对照组升高更为显著(P<0.05)。结论:丹红注射液可有效降低UAP患者血清ET-1、hs-CRP、Fg及TNF-α水平水平,升高血清NO水平,具有抑制炎症反应、改善血管内皮功能的良好作用。
关键词 丹红注射液 不稳定型心绞痛 血管内皮功能 炎症因子
表-1 两组患者治疗前后血清ET-1、NO水平比较( ±S)
注:丹红组治疗前后比较,★P<0.01;常规组治疗前后比较,◇P<0.05;两组治疗后比较,▲ P<0.05。
表-2 两组患者治疗前后血清hs-CRP、Fg及TNF-α水平比较( ±S)
注:丹红组治疗前后比较,△P<0.01;常规组治疗前后比较,◆P<0.05;两组治疗后比较,☆ P<0.05。 展开
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Topic: Dan red injection of unstable angina patients with vascular endothelial function and influence of inflammatory markers
The author units: nanjing university of traditional Chinese medicine clinical medical school
Objective: to explore Dan red injection to unstable angina (UAP) patients with vascular endothelial dysfunction related factors, inflammatory factor leels influence. Methods: 72 cases according to the principle of 1:1 UAP patients were randomly divided into the treatment group (Dan red group) and control group (36 cases of conventional group) 36 cases and control; to conventional treatments. In treatment group based on conventional drugs to Dan red injection therapy (Dan red injection 30ml + physiological saline, 250ml ivgtt, qd), treatment for two weeks. Test before and after the treatment of serum endothelin - 1 (ET - 1), nitric oxide (NO), allergic c-reactive protein (hs) - the fibrinogen CRP), (Fg), tumor necrosis factor (TNF alpha (alpha) level changes. Results: treatment before two groups patients serum ET - 1, hs - CRP, Fg and TNF alpha levels were significantly increased, serum level is aubject are obviously decreased, the treatment group serum ET - 1, hs - CRP, Fg and TNF alpha level is more significant decline control group (P < 0.05), serum level was elevated aubject to control more significant (P < 0.05). Conclusion: Dan red injection can effectively reduce the UAP patients serum ET - 1, hs - CRP, Fg and TNF alpha level level, increase serum aubject level, can inhibit inflammation, improves endothelial function of good effect.
Keywords Dan red injection unstable angina endothelial function of proinflammatory factor
Table - 1 two groups of patients before and after the treatment of serum ET - 1, NO level is (+ S)
Note: Dan red group compared before and after treatment, P < 0.01; u Conventional group compared before and after treatment, P < 0.05); so The two groups after treating comparison, ▲ P < 0.05.
Table 2-2 groups before and after the treatment of serum hs - CRP, Fg and TNF alpha level is (+ S)
Note: Dan red treatment group before-and-after, enables delta P < 0.01, Conventional treatment group before-and-after, a P < 0.05, The two groups after treating comparison, ☆ P < 0.05.
The author units: nanjing university of traditional Chinese medicine clinical medical school
Objective: to explore Dan red injection to unstable angina (UAP) patients with vascular endothelial dysfunction related factors, inflammatory factor leels influence. Methods: 72 cases according to the principle of 1:1 UAP patients were randomly divided into the treatment group (Dan red group) and control group (36 cases of conventional group) 36 cases and control; to conventional treatments. In treatment group based on conventional drugs to Dan red injection therapy (Dan red injection 30ml + physiological saline, 250ml ivgtt, qd), treatment for two weeks. Test before and after the treatment of serum endothelin - 1 (ET - 1), nitric oxide (NO), allergic c-reactive protein (hs) - the fibrinogen CRP), (Fg), tumor necrosis factor (TNF alpha (alpha) level changes. Results: treatment before two groups patients serum ET - 1, hs - CRP, Fg and TNF alpha levels were significantly increased, serum level is aubject are obviously decreased, the treatment group serum ET - 1, hs - CRP, Fg and TNF alpha level is more significant decline control group (P < 0.05), serum level was elevated aubject to control more significant (P < 0.05). Conclusion: Dan red injection can effectively reduce the UAP patients serum ET - 1, hs - CRP, Fg and TNF alpha level level, increase serum aubject level, can inhibit inflammation, improves endothelial function of good effect.
Keywords Dan red injection unstable angina endothelial function of proinflammatory factor
Table - 1 two groups of patients before and after the treatment of serum ET - 1, NO level is (+ S)
Note: Dan red group compared before and after treatment, P < 0.01; u Conventional group compared before and after treatment, P < 0.05); so The two groups after treating comparison, ▲ P < 0.05.
Table 2-2 groups before and after the treatment of serum hs - CRP, Fg and TNF alpha level is (+ S)
Note: Dan red treatment group before-and-after, enables delta P < 0.01, Conventional treatment group before-and-after, a P < 0.05, The two groups after treating comparison, ☆ P < 0.05.
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