Question

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尼群地平为二氢吡啶类钙通道阻滞剂。具有显著而持久的降压及血管扩张作用。本设计是经综合比较国内外有关尼群地平合成工艺的优缺点，本着环境友好、缩短时间和适合工业化生产等目的，优选了以3-硝基苯甲醛和乙酰乙酸乙酯以及β-氨基巴豆酸甲酯为原料的合成路线，经过亚甲基化和烷基化反应制得了尼群地平。
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Answer 1

Nitrendipine to dihydropyridine calcium channel blockers. A significant and lasting blood pressure and vascular dilatation. Comprehensive comparison of the design is at home and abroad by the synthesis process on the advantages and disadvantages of nitrendipine, in environmentally friendly, reducing the time and is suitable for industrial production purposes, optimized for 3 - nitrobenzaldehyde and ethyl acetoacetate and β-amino crotonic acid methyl ester as raw material for synthetic route, through the methylene and alkylation reaction had nitrendipine.

Answer 2

Nehemiah group of the flat earth for dihydrogen pyridine classes calcium channel blockers. Significant and lasting step-down and hemal dilate role. This design is the comprehensive comparison of domestic and foreign relevant nehemiah the advantages and disadvantages of the flat earth synthesis process, in line with the environment friendly, shorten the time and suitable for industrial production, the optimum for purposes such as with 3 - and anmmonium ethyl allylacetoacetate and beta BaDou amino acid methyl ester as raw material of synthetic route, after the methylation and alkylated reaction system, group of the flat earth had.