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高分求助英文文献，QQ908996455，在线等...

高分求助英文文献，QQ908996455，在线等...
Sebbag Mireille; Moinard Nathalie; Auger Isabelle; Clavel Cyril; Arnaud Jacques; Nogueira Leonor; Roudier Jean; Serre Guy
Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins.
European journal of immunology 2006;36(8):2250-63
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Answer 1

sebbag米雷列;moinard娜塔莉;钻伊莎贝尔;克拉韦尔西里尔;彼德鲁庄园由阿诺德雅克;麻省总医院诺盖拉女人名;第二牛仔裤;塞尔家伙人的的表位纤维蛋白承认被类风湿arthritis-specific自身抗体citrullinated蛋白。印刷期刊2006;36(8):2250-63

Answer 2

Abstract
Formation of the epitopes recognized by the rheumatoid arthritis (RA)-specific autoantibodies to citrullinated proteins (ACPA) on filaggrin and on the alpha- and beta-chains of fibrin, their synovial target, requires conversion of their arginyl residues into citrullyl residues, but is also affected by their amino-acyl environment. Using competition with five citrullinated filaggrin-derived peptides bearing major ACPA epitopes, we confirmed the close cross-reactivity between filaggrin and citrullinated fibrin. To identify the sequential epitopes recognized on fibrin by ACPA, 71 citrullinated 15-mer peptides derived from all the sites of the alpha- and beta-chains of fibrin harboring arginyl residues were tested by ELISA using ACPA-positive RA sera exhibiting different reactivity profiles to the five filaggrin peptides. We identified 18 fibrin-derived peptides bearing ACPA epitopes. Regarding the ability of fibrinogen arginyl residues to be citrullinated in vitro, 11 of the peptides likely correspond to in vivo targeted epitopes. Two out of them bear major epitopes and are located in the central globular domain of the protein. In the synovial tissue, fibrin citrullination and ACPA binding could impair fibrin degradation by plasmin. The immunological conflict between ACPA and fibrin could therefore sustain synovial inflammation not only via pro-inflammatory effector mechanisms but also via impairment of fibrinolysis.

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Answer 3

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