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Itisgenerallyacceptedthatlocomotioninmammals,includinghumans,isbasedontheactivityofne... It is generally accepted that locomotion in mammals, including humans, is based on the activity of neuronal circuits within the spinal cord
(the central pattern generator, CPG). Afferent information from the periphery (i.e. the limbs) influences the central pattern and, conversely,
the CPG selects appropriate afferent information according to the external requirement. Both the CPG and the reflexes that mediate afferent
input to the spinal cord are under the control of the brainstem. There is increasing evidence that in central motor diseases, a defective
utilization of afferent input, in combination with secondary compensatory processes, is involved in typical movement disorders, such as
spasticity and Parkinson’s disease. Recent studies indicate a plastic behavior of the spinal neuronal circuits following a central motor lesion.
This has implications for any rehabilitative therapy that should be directed to take advantage of the plasticity of the central nervous system.
The significance of this research is in a better understanding of the pathophysiology underlying movement disorders and the consequences for
an appropriate treatment.
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2011-02-22 · TA获得超过245个赞
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人们普遍认为运动在哺乳动物中,包括人类,是基于神经细胞线路的活动在脊髓的过程
(《中枢模式发生器、)。传入信息(如下从预备队。四肢的)影响中枢模式,同样,
中央人民政府选择适当的传入信息根据外部要求。两个中央人民政府和反应,调解传入
输入到脊髓完全控制在脑干。越来越多的证据表明在运动中枢疾病、缺陷
利用传入输入,结合二次补充过程、参与典型的运动障碍等
痉挛状态和帕金森病。最近的研究表明塑料行为的神经细胞线路后脊柱运动中枢病变。
提示在任何康复治疗应该直接利用的可塑性中枢神经系统。
本研究的重要性在病理生理学的更好的理解以及结果基本运动障碍
适当的治疗
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