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Acorrelationofthesestructuraldatawithcellulartransfectionefficienciesrevealsthatthehi...
A correlation of these structural data with cellular transfection efficiencies reveals that the highest transfection efficiency is obtained with those amphiphiles that are easily hydrated,form fluid aggregates,and undergo a transition to the inverted hexagonal phase in the presence of plasmid DNA(p-DNA)at physiological ionic strength.
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2011-02-23 · 知道合伙人自然科学行家
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A correlation of these structural data with cellular transfection efficiencies reveals that the highest transfection efficiency is obtained with those amphiphiles that are easily hydrated,form fluid aggregates,and undergo a transition to the inverted hexagonal phase in the presence of plasmid DNA(p-DNA)at physiological ionic strength.
结构数据与细胞转染效率的关联性显示,易于水合的两亲化合物具有最高的转染效率,它可形成流体聚集体,并在生理离子强度以及质体DNA(p-DNA) 的存在下,发生向六角相的转变。
Cationic amphiphiles are considered promising alternatives for viral vectors in gene therapy due to the negligible immunogenicity,relative ease of large-scale production and amenability for structural modification.
一般认为,阳离子性两亲化合物在基因治疗中,可以作为病毒载体的绝佳替代物,这归因于以下三点:它几乎没有免疫原性;其规模化生产相对易于实现;其结构改性具有可控性。
结构数据与细胞转染效率的关联性显示,易于水合的两亲化合物具有最高的转染效率,它可形成流体聚集体,并在生理离子强度以及质体DNA(p-DNA) 的存在下,发生向六角相的转变。
Cationic amphiphiles are considered promising alternatives for viral vectors in gene therapy due to the negligible immunogenicity,relative ease of large-scale production and amenability for structural modification.
一般认为,阳离子性两亲化合物在基因治疗中,可以作为病毒载体的绝佳替代物,这归因于以下三点:它几乎没有免疫原性;其规模化生产相对易于实现;其结构改性具有可控性。
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这些关联结构化数据显示,随着蜂窝transfection效率最高的效率与transfection得到试剂,易保湿,形成流体的骨料、接受过渡到倒六角阶段质体DNA(的存在)p-DNA生理离子强度
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Cationic amphiphiles are considered promising alternatives for viral vectors in gene therapy due to the negligible immunogenicity,relative ease of large-scale production and amenability for structural modification.
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