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Astheonlymemberofthereplicationapparatusuniquelyrequiredattheorigin,dnaAhasattractedm...
As the only member of the replication apparatus uniquely required at the origin,dnaA has attracted much attention.dnaA is a target for several regulatory systems.it may be that no one of these systems alone is adequate to control frequency of initiation,but that when combined they achieve the desired result.some mutations in dnaA render replication asynchronous,which suggests that dnaA could be the “titrator”or”clock”that measures the number of dnaA yields conflicting results,which vary from no effect to causing initiation to take place at reduced mass.
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