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Adivergentsyntheticapproachtonewsultamsutilizingintramolecularoxa-MichaelandBaylis-Hi...
A divergent synthetic approach to new sultams utilizing intramolecular oxa-Michael and Baylis-Hillman reactions of readily prepared vinyl sulfonamides and suitably protected amino alcohols, is reported. A variety of seven- and eight-membered ring sultam scaffolds were synthesized using oxa-Michael pathways, whereas both five- and six-membered rings were synthesized using Baylis-Hillman methods. Baylis-Hillman reactions proceed with good to excellent levels of diastereoselectivity, and oxa-Michael reactions leading to eight-membered ring sultams provide empirical evidence validating 8-endo-trig cyclization pathways.
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A divergent synthetic approach to new sultams utilizing intramolecular oxa-Michael and Baylis-Hillman reactions of readily prepared vinyl sulfonamides and suitably protected amino alcohols, is reported.据报道现已经发明了一种新磺内酰胺的扩散合成方法,这种方法是利用预制备的乙烯基磺胺以及,经适当保护的氨基乙醇之间的oxa-Michael分子内加成反应和贝里斯-希尔曼反应。
A variety of seven- and eight-membered ring sultam scaffolds were synthesized using oxa-Michael pathways, whereas both five- and six-membered rings were synthesized using Baylis-Hillman methods.
通过oxa-Michael反应,可以合成各种七元环和八元环的磺内酰胺支架,然而五元环和六元环的磺内酰胺是通过贝里斯-希尔曼反应的方法来合成的。
Baylis-Hillman reactions proceed with good to excellent levels of diastereoselectivity, and oxa-Michael reactions leading to eight-membered ring sultams provide empirical evidence validating 8-endo-trig cyclization pathways.
随着非对应立体选择性由优良级别向优秀级别的转变,贝里斯-希尔曼反应继续进行着;生成八元环磺内酰胺的oxa-Michael反应提供了可以证实8-琼脂-3-环环化的实验证据
A variety of seven- and eight-membered ring sultam scaffolds were synthesized using oxa-Michael pathways, whereas both five- and six-membered rings were synthesized using Baylis-Hillman methods.
通过oxa-Michael反应,可以合成各种七元环和八元环的磺内酰胺支架,然而五元环和六元环的磺内酰胺是通过贝里斯-希尔曼反应的方法来合成的。
Baylis-Hillman reactions proceed with good to excellent levels of diastereoselectivity, and oxa-Michael reactions leading to eight-membered ring sultams provide empirical evidence validating 8-endo-trig cyclization pathways.
随着非对应立体选择性由优良级别向优秀级别的转变,贝里斯-希尔曼反应继续进行着;生成八元环磺内酰胺的oxa-Michael反应提供了可以证实8-琼脂-3-环环化的实验证据
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2011-05-02
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一个不同的合成方法,利用新sultams分子氧杂迈克和磺胺类药物和乙烯随时准备适当的保护氨基醇的Baylis - Hillman反应,报道。阿七和八元环sultam支架,而使用了各种合成同时五和六元环氧杂迈克尔途径,用合成的Baylis - Hillman方法。的Baylis - Hillman反应进行良好的非对映选择性优良水平,氧杂Michael反应,导致八元环sultams提供实验证据证实8远藤- trig的环化途径。
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