Question

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Membranes of Chitosan for Haemodialysis
Cellulose and cuprophan based membranes have no selectivity in the separation of two closely related molecules, during hemodialysis, new membranes with permselectivity,mechanical properties and blood compatibility are needed. Hirano prepared a series of membranes from chitosan and its derivatives that showed improved dialysis properties. However,the most serious limitation of all the above membranes is the surface-induced thrombosis, which requires heparinization of blood to prevent clotting.
Surface modification of albumin chitosan blended membranes have been reported by us, via immobilization of bioactive complexes or coupling biomolecules on liposome-modified membranes through carbodiimide functional moieties . However, the wet tear strength of chitosan-based membranes needs to be improved with their nonthrombogenic functions. Hence,nonthrombogenic Polyvinyl alcohol (PVA) Blended chitosan membranes have been derived by immobilizing bioactive molecules like PGE, on heparin-modified membranes, via free radical mechanisms,by nitrogen plasma. This novel membrane demonstrated improved strength properties, blood compatibility and good permeability functions for small molecules.
Chitosan Matrix for Drug Delivery
Recent attention has concentrated on the use of cheap raw materials and on simplifying the formulations for controlled release therapies. Our studies have shown that steroids dispersed in chitosan films or beads can release the drug at a constant rate for prolonged periods.Further,chitosan has gel forming properties in the low pH range, and also with its antacid and antiulcer characteristics,may prevent or weaken drug irritation in the stomach. Hence it has potential for use as an oral sustained delivery system.
As indicated earlier, the mechanism of drug release may be due to diffusion through the swollen beads,which have been dependent upon the pH of the media. Chitosan has also been used for deliverying ferric ions and protamine sulfate, to prevent calcification of bovine pericardium and porous polyurethane. Hence, it appears that chitosan might be a promising vehicle for sustained-release oral preparations and for prolonged drug delivery.
Chjitosan Matrix for removal of Toxins
Activated charcoal is commonly used for impurity and toxin removal.However, the use of activated charcoal for hemoperfusion has been limited due to the release of carbon fines and platelet depletion. These side effects can be eliminated by fine coatings of polymers on activated charcoal. The earlier report from this laboratory have indicated the preparation and performance of chitosan encapsulated activated charcoal (ACCB) for the removal of toxins from blood.

Answer 1

膜壳聚糖洗肾纤维素和cuprophan基膜没有选择性的分离两个密切相关 分子,在血液透析,新的膜具有渗透性,力学性能和血液相容性的需要. 平野编写了一系列膜,壳聚糖及其衍生物,有明显改善透析性能. 然而,最严重的限制上述所有膜表面诱发血栓形成, 需要肝素血液,以防止凝结. 表面修饰白蛋白混纺壳聚糖膜已报道的时候, 经固定化生物活性物或生物大分子耦合对脂质体膜修饰通过碳化功能材料. 然而,泪湿强度壳聚糖膜的需要加以改进,其nonthrombogenic职能. 因此, nonthrombogenic聚乙烯醇( PVA )共混壳聚糖膜已导出了固定生物活性分子如铂,肝素修饰膜 通过自由基机制,以氮等离子体. 这部小说表现出膜改善强度性能,血液相容性和良好的透气功能的小分子物质. 壳聚糖为基质释药最近注意力都集中使用了廉价的原材料和简化 剂型为缓释疗法. 我们的研究表明,类固醇分散在壳聚糖膜或珠子可释放药物恒速 长时间periods.further ,壳聚糖凝胶成形性能,在低pH值范围内, 并与它的抗酸和抗溃疡特性,可避免或减弱药物刺激胃部. 因此,有潜力用作口头持续交收制度. 如前所述, 机制的药物释放可能是由于扩散透过肿珠,所依赖的pH 传播媒介. 壳聚糖也已用于娩出铁离子和硫酸鱼精蛋白, 防止钙化牛心包和多孔质聚氨酯. 因此看来,壳聚糖可能是一个大有可为的车辆缓释口服制剂和长期给药. chjitosan矩阵去除毒素活性炭是常用的杂质和毒素removal.however , 使用活性碳血液一直受限于释放碳罚款和血小板消耗. 这些副作用是可以消除的罚款涂料聚合物对活性炭. 早先的报告,由这个实验室已表示制备及性能的壳聚糖微囊活性炭( accb )为 去除毒素从血液.

Answer 2

Chitosan的膜为血液透析
纤维素和cuprophan基于膜没有选择性在二个紧密地相关的分子，在血液透析期间，新的膜与permselectivity，机械性能和血液的分离因此, nonthrombogenic聚乙烯醇( PVA )共混壳聚糖膜已导出了固定生物活性分子如铂,肝素修饰膜 通过自由基机制,以氮等离子体. 这部小说表现出膜改善强度性能,血液相容性和良好的透气功能的小分子物质. 壳聚糖为基质释药最近注意力都集中使用了廉价的原材料和简化 剂型为缓释疗法. 我们的研究表明,类固醇分散在壳聚糖膜或珠子可释放药物恒速 长时间periods.further ,壳聚糖凝胶成形性能,在低pH值范围内, 并与它的抗酸和抗溃疡特性,可避免或减弱药物刺激胃部. 因此,有潜力用作口头持续交收制度. 如前所述, 机制的药物释放可能是由于扩散透过肿珠,所依赖的pH 传播媒介. 壳聚糖也已用于娩出铁离子和硫酸鱼精蛋白, 防止钙化牛心包和多孔质聚氨酯. 因此看来,壳聚糖可能是一个大有可为的车辆缓释口服制剂和长期给药. chjitosan矩阵去除毒素活性炭是常用的杂质和毒素removal.however , 使用活性碳血液一直受限于释放碳罚款和血小板消耗. 这些副作用是可以消除的罚款涂料聚合物对活性炭. 早先的报告,由这个实验室已表示制备及性能的壳聚糖微囊活性炭( accb )为 去除毒素从血液.