医学论文摘要翻译
左乙拉西坦单药治疗癫痫患者的临床疗效及脑电活动影响的研究[摘要]:目的:探讨左乙拉西坦(LEV)对新诊断的癫痫患者临床疗效及脑电活动的影响。方法:LEV单药治疗新诊断的1...
左乙拉西坦单药治疗癫痫患者的临床疗效及脑电活动影响的研究
[摘要]:目的:探讨左乙拉西坦(LEV)对新诊断的癫痫患者临床疗效及脑电活动的影响。方法:LEV单药治疗新诊断的120例癫痫患者,进行开放性自身对照随访研究。观察LEV治疗后2个月、6个月及12个月时的临床疗效、对发作间期痫样放电、脑电背景活动的影响。结果:治疗后2个月、6个月及12月后总有效率分别为 89.2 %、 82.5%及 77.5%。脑电发作间期痫样放电(IEA)消失或减少50.0%以上分别为48.3 %、50.0 %及52.5 %。治疗六个月后脑电地形图和θ、δ频段相对功率与治疗前相对功率降低,α频段相对功率相对增加,β频段相对功率无明显变化。结论:左乙拉西坦单药治疗新诊断的各种癫痫发作有较好的疗效,安全性良好,并可使痫样放电减少或消失,并能改善脑电背景活动。
[关键词]:癫痫;左乙拉西坦;发作间期痫样放电;脑电图 展开
[摘要]:目的:探讨左乙拉西坦(LEV)对新诊断的癫痫患者临床疗效及脑电活动的影响。方法:LEV单药治疗新诊断的120例癫痫患者,进行开放性自身对照随访研究。观察LEV治疗后2个月、6个月及12个月时的临床疗效、对发作间期痫样放电、脑电背景活动的影响。结果:治疗后2个月、6个月及12月后总有效率分别为 89.2 %、 82.5%及 77.5%。脑电发作间期痫样放电(IEA)消失或减少50.0%以上分别为48.3 %、50.0 %及52.5 %。治疗六个月后脑电地形图和θ、δ频段相对功率与治疗前相对功率降低,α频段相对功率相对增加,β频段相对功率无明显变化。结论:左乙拉西坦单药治疗新诊断的各种癫痫发作有较好的疗效,安全性良好,并可使痫样放电减少或消失,并能改善脑电背景活动。
[关键词]:癫痫;左乙拉西坦;发作间期痫样放电;脑电图 展开
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[ Abstract ]: Objective: To investigate the left levetiracetam ( LEV ) for newly diagnosed patients with epilepsy clinical curative effect and influence of cerebral electrical activity. Methods: LEV monotherapy in newly diagnosed epilepsy in 120 cases, to open their own controlled follow-up study. Observation of LEV after treatment for 2 months, 6 months and 12 months, the clinical curative effect of interictal epileptiform discharges, EEG background activity effect. Results: after treatment for 2 months, 6 months and in December after the total efficiency is respectively 89.2%, 82.5% and 77.5%. EEG interictal epileptiform discharges ( IEA ) disappeared or reduced by more than 50% respectively 48.3%, 50% and 52.5%. Treatment of six months after brain electrical activity mapping and theta, delta band relative to power before treatment with relative power reduction, alpha power increases relatively, beta band relative power without obvious changes. Conclusion: left levetiracetam monotherapy in the treatment of newly diagnosed seizures has better curative effect, good safety, and can make the epileptiform discharges decreased or disappeared, and can improve the EEG background activities.[Key words ]: epilepsy; left levetiracetam; interictal epileptiform discharges; electroencephalogram
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