Question

跪求翻译，麻烦各位大侠了！！！

Abstract Epigenetic silencing of the O6-methylguanine-DNA methyltransferase (MGMT) gene is associated withimproved survival in patients with high-grade gliomas (HGG), with varying estimates of magnitude. The objective of this meta-analysis is to determine the prognostic value of MGMT silencing, and assess its predictive value by treatment type. MEDLINE and EMBASE databases were searched for studies relating to gliomas and MGMT. Studies reporting overall survival (OS) by MGMT status in patients with HGG were considered potentially eligible. We excluded studies that did not control for potential confounding variables. A meta-analysis of studies was performed via random-effects modelling.

Answer 1

摘要后生沉默的O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）的基因关联withimproved在高级别胶质瘤（HGG）患者的生存，不同幅度的估计。这项荟萃分析的目的是确定MGMT的沉默的预后价值，评估其治疗类型的预测值。 MEDLINE和EMBASE数据库进行了全面搜查胶质瘤和MGMT的研究。研究报告HGG患者MGMT的状态整体存活率（OS），被认为是潜在的资格。我们排除在外，没有控制潜在的混杂变量的研究。通过随机效应模型进行荟萃分析的研究。

Answer 2

摘要表观遗传关闭O6-methylguanine-DNA methyltransferase(管理)基因有关患者的生存withimproved高档神经胶质瘤(HGG),用不同大小的估计。这个荟萃分析的目的是为了确定管理沉默的预测值,并评估其预测价值类型的治疗。MEDLINE和EMBASE数据库检索有关神经胶质瘤研究和管理。研究报告(OS)总体存活患者管理现状HGG被认为是潜在的资格。我们排除研究没有控制潜在的混杂变量。研究的荟萃分析切除术随机影响的造型。

Answer 3

摘要表观遗传关闭O6-methylguanine-DNA methyltransferase(管理)基因有关患者的生存withimproved高档神经胶质瘤(HGG),用不同大小的估计。这个荟萃分析的目的是为了确定管理沉默的预测值,并评估其预测价值类型的治疗。MEDLINE和EMBASE数据库检索有关神经胶质瘤研究和管理。研究报告(OS)总体存活患者管理现状HGG我们