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surfaceareawascalculatedtobe323m2/g.AlthoughporesseemedtobepartiallyblockedbyFe3O4nan... surface area was calculated to be 323 m
2
/g. Although pores
seemed to be partially blocked by Fe
3O4
nanocrystals, the
surface area of Fe
3O4
-MSN was sufficiently large for use as a
drug delivery vehicle.
Because the superparamagnetic characteristics of the Fe 3O4
nanocrystals accelerate the transverse relaxation of water
protons, Fe
3O4
-MSN could be used as a T2 contrast agent in
MRI. It is well reported that assembled or aggregated super-
paramagnetic nanoparticles can remarkably enhance MR signals
due to synergistic magnetism.
11
Transverse (T2) relaxation times
of protons from the dispersion containing Fe
3O4
-MSN were
measured and compared to that of free Fe3O4
nanocrystals. The
Figure 2. MR signal enhancement by Fe 3 O 4
-MSN. (a) Plot of inverse
transverse relaxation times (1/T2) versus Fe concentration. The slope
indicates the specific relaxivity value, r
2
. (b) T2 weighted MR image of
Fe
3O4
-MSN and free Fe
3O4
. Darker signal was observed for Fe
3O4-MSN
at the same concentration of Fe, and specific relaxivity value r
2
increased
by 2.8 times as compared to free Fe
3O4
.
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表面面积测算为323米
2
/ g。虽然毛孔
似乎是通过有限元部分堵塞
3 O4
奈米,
表面积铁
3 O4
-MSN是足够大的作为
药物递送的车辆。
因为超顺磁性特征的3 O4铁
奈米晶体横向放松加速水
质子、铁
3 O4
-MSN可以用作T2造影剂
核磁共振成像。这是一个很好的报道,组装或聚集超级-
顺磁性纳米粒子先生能显著提高信号
由于协同的磁性。
11
横向(T2)松弛时间
从分散的质子含有铁
3 O4
-MSN是
测量与自由Fe3O4相比
奈米晶体。这
图2。磁共振信号增强铁阿4
-MSN。 (一)块逆
横向松弛时间(1 / T2)和铁的浓度。边坡
指出具体relaxivity价值,r
2
。(b)的形象T2加权先生

3 O4
-MSN和自由铁
3 O4
。观察深信号对铁
3 O4-MSN
在相同浓度铁、和具体relaxivity值r
2
增加
2.8倍比较自由队
3 O4
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