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缺氧诱导因子-1和血管内皮生长因子在鼻咽癌组织中的表达及其意义摘要:目的:探讨缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的阳性表达及与临床病理特征的关系。方法:本科题应...
缺氧诱导因子- 1和血管内皮生长因子
在鼻咽癌组织中的表达及其意义
摘要:
目的:探讨缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的阳性表达及与临床病理特征的关系。
方法:本科题应用免疫组化S-P染色法,检测52例鼻咽癌组织中缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的阳性表达,同时取20例鼻咽炎症组织,作对照并作统计学处理。
结果:52例鼻咽癌组织中缺氧诱导因子-1与血管内皮生长因子的表达阳性率分别为57.7%(30/52)和63.5%(33/52),缺氧诱导因子-1与血管内皮生长因子阳性染色均呈棕黄色细颗粒状着色,前者表达于细胞核,后者表达于细胞浆。鼻咽炎症组织缺氧诱导因子-1与血管内皮生长因子的表达均呈阴性,两者与癌组织比较有非常显著性差异(P<0.01)。
氧诱导因子-1在鼻咽癌组织中的阳性表达在病理分级中低分化鳞癌较高、中分化鳞癌增高,两者比较有显著性差异(X2=5.332, P<0.05);同时也随T分期的增加而增高(X2=3.989, P<0.05),Ⅲ、Ⅳ鼻咽癌组织的阳性表达率显著高于Ⅰ,Ⅱ期(X2=5.543, P<0.05),有颈淋巴结转移的鼻咽癌组织中的HIF-1α表达显著高于无淋巴结转移的鼻咽癌(X2=5.822, P<0.05)。同样,血管内皮生长因子在鼻咽癌组织中阳性表达随病理分化程度低、T分期增加而增高(X2=5.889, P<0.05;X2=9.871, P<0.01);Ⅲ、Ⅳ期鼻咽癌组织的阳性表达率显著高于Ⅰ、Ⅱ期鼻咽癌组织的表达(X2=6.449, P<0.05), 有颈淋巴结转移者其阳性表达显著高于无淋巴结转移者(X2=7.102, P<0.01)。缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的表达阳性率呈正相关。
结论:缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中有较高的阳性表达,同时也随病理分化、临床分期、颈淋巴结转移其阳性表达率随病程发展而增高,可作为早期诊断鼻咽癌的辅助指标之-,并可作为判断鼻咽癌预后的重要指标。
关键词:鼻咽癌 缺氧诱导因子-1 血管内皮生长因子
免疫组织化学 预后
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊 展开
在鼻咽癌组织中的表达及其意义
摘要:
目的:探讨缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的阳性表达及与临床病理特征的关系。
方法:本科题应用免疫组化S-P染色法,检测52例鼻咽癌组织中缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的阳性表达,同时取20例鼻咽炎症组织,作对照并作统计学处理。
结果:52例鼻咽癌组织中缺氧诱导因子-1与血管内皮生长因子的表达阳性率分别为57.7%(30/52)和63.5%(33/52),缺氧诱导因子-1与血管内皮生长因子阳性染色均呈棕黄色细颗粒状着色,前者表达于细胞核,后者表达于细胞浆。鼻咽炎症组织缺氧诱导因子-1与血管内皮生长因子的表达均呈阴性,两者与癌组织比较有非常显著性差异(P<0.01)。
氧诱导因子-1在鼻咽癌组织中的阳性表达在病理分级中低分化鳞癌较高、中分化鳞癌增高,两者比较有显著性差异(X2=5.332, P<0.05);同时也随T分期的增加而增高(X2=3.989, P<0.05),Ⅲ、Ⅳ鼻咽癌组织的阳性表达率显著高于Ⅰ,Ⅱ期(X2=5.543, P<0.05),有颈淋巴结转移的鼻咽癌组织中的HIF-1α表达显著高于无淋巴结转移的鼻咽癌(X2=5.822, P<0.05)。同样,血管内皮生长因子在鼻咽癌组织中阳性表达随病理分化程度低、T分期增加而增高(X2=5.889, P<0.05;X2=9.871, P<0.01);Ⅲ、Ⅳ期鼻咽癌组织的阳性表达率显著高于Ⅰ、Ⅱ期鼻咽癌组织的表达(X2=6.449, P<0.05), 有颈淋巴结转移者其阳性表达显著高于无淋巴结转移者(X2=7.102, P<0.01)。缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中的表达阳性率呈正相关。
结论:缺氧诱导因子-1与血管内皮生长因子在鼻咽癌中有较高的阳性表达,同时也随病理分化、临床分期、颈淋巴结转移其阳性表达率随病程发展而增高,可作为早期诊断鼻咽癌的辅助指标之-,并可作为判断鼻咽癌预后的重要指标。
关键词:鼻咽癌 缺氧诱导因子-1 血管内皮生长因子
免疫组织化学 预后
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊
请高手们帮忙啊,机器直译的太多错误,我不会改啊 展开
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Hypoxia-inducible factor - 1 and vascular endothelial growth factor
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
我倒了,好累,好累
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
我倒了,好累,好累
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2008-03-30
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书上有,我见过,帮你找找。。。
不知道能不能打完,太多了。。。
鄙视那些网上抄来害人的垃圾!!!
Hypoxia-inducible factor - 1 and vascular endothelial growth factor
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
靠,累死了
最后一句不知道有用没
分开打吧,看的方便
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
不知道能不能打完,太多了。。。
鄙视那些网上抄来害人的垃圾!!!
Hypoxia-inducible factor - 1 and vascular endothelial growth factor
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
靠,累死了
最后一句不知道有用没
分开打吧,看的方便
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
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Hypoxia-inducible factor - 1 and vascular endothelial growth factor
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
In the expression of nasopharyngeal carcinoma and its significance
Abstract:
Objective: To investigate the hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma, the positive expression with clinical and pathological features of the relationship.
Methods: Undergraduate and that of SP immunohistochemical staining detected 52 cases of nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor in the positive nasopharyngeal carcinoma, and 20 cases of nasopharyngeal inflammation from the Organization for for control and statistical analysis.
Results: 52 patients with nasopharyngeal carcinoma tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression positive rates were 57.7% (30/52) and 63.5% (33/52), and hypoxia-inducible factor-1 and vascular Endothelial Growth Factor showed positive staining fine granular brown coloring, the former expressed in the nucleus, the latter expressed in the cytoplasm. Nasopharyngeal inflammatory tissue hypoxia-inducible factor-1 and vascular endothelial growth factor expression were negative, the two organizations compared with cancer there was a significant difference (P <0.01).
Oxygen-inducible factor-1 in nasopharyngeal carcinoma, the positive expression in the pathological grade of carcinoma higher differentiated squamous cell carcinoma increased, and there is a significant difference (X2 = 5.332, P <0.05) at the same time also with the increase in T stage and increased (X2 = 3.989, P <0.05), Ⅲ, Ⅳ expression nasopharyngeal carcinoma was significantly higher than that Ⅰ, Ⅱ (X2 = 5.543, P <0.05), cervical lymph node nasopharyngeal carcinoma metastasis of the HIF-1 α expression were significantly higher than those without lymph node metastasis of nasopharyngeal carcinoma (X2 = 5.822, P <0.05). Similarly, vascular endothelial growth factor in the positive expression in nasopharyngeal carcinoma with a low degree of pathological differentiation, increased higher T stage (X2 = 5.889, P <0.05; X2 = 9.871, P <0.01); Ⅲ, Ⅳ nasopharyngeal The positive expression of cancer was significantly higher than that Ⅰ, Ⅱ expression nasopharyngeal carcinoma (X2 = 6.449, P <0.05), cervical lymph node metastasis its expression was significantly higher than those without lymph node metastasis (X2 = 7.102, P <0.01). Hypoxia-inducible factor-1 and vascular endothelial growth factor expression in nasopharyngeal carcinoma positive rate was positively correlated.
Conclusion: hypoxia-inducible factor-1 and vascular endothelial growth factor in nasopharyngeal carcinoma have a higher expression, but also with the pathology division, clinical stage, cervical lymph node metastasis of its positive rate increased with the development of the course, as Early diagnosis of nasopharyngeal carcinoma auxiliary indicators -, as a judge and an important indicator of prognosis of nasopharyngeal carcinoma.
Key words: nasopharyngeal carcinoma of hypoxia-inducible factor-1 Vascular Endothelial Growth Factor
Immunohistochemistry prognosis
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饿酿一,这噶子不好整,忒职业了!
拿分,飘人!
拿分,飘人!
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看着眼累。。。
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