Question

求大神帮忙翻译，谢谢~~

Background: Multiple platelet exposure induces anti-HLA and/or anti-HPA antibody production,which may cause platelet transfusion refractoriness (PTR). In Japan, the universal pre-storage leukocyte reduction (ULR) was fully implemented since 2006, but prior to ULR,in our institution, leukocyte reduction filters were routinely used at the bedside (bedside leukoreduction, BSLR) for all onco-hematological patients receiving multiple platelet transfusions.
Objective: We retrospectively compared patients receiving platelet transfusions in the era of ULR with those of BSLR era.
Materials and methods: Patients of the BSLR group (409 cases) and the ULR group (586 cases)were compared in terms of alloimmunization and immunological PTR. The clinicopathological features, including gender, history of pregnancy, number of exposed transfusion donors, periods of transfusion, and prior stem cell transplantation were compared, and the risk factors of alloimmunization were determined.
Results: The antibody detection rate was significantly higher in the ULR compared to BSLR group (8.7% vs. 5.4%), as well as the immunological PTR rate (7.3% vs. 3.2%). By the multivariate analysis, female gender and the number of platelet donor exposure, but not universal leukoreduction or transfusion period, were found to be the risk factors strongly associated with alloantibody formation.
Conclusion: Although ULR may be superior to BSLR in terms of preventing non-hemolytic transfusion reactions, BSLR was found to be as effective as ULR in terms of preventing platelet alloimmunization and refractoriness. Thus, BSLR should be actively indicated as a realistic alternative in developing countries, before the universal leukoreduction is fully implemented.

Answer 1

背景:多个血小板接触诱发anti-HLA和/或anti-HPA抗体的生产,这可能会导致血小板输血耐火度(PTR)。在日本,通用贮前白细胞减少(ULR)全面实施自2006年以来,但ULR之前,在我们的机构中,白细胞减少过滤器经常使用在床边(所有onco-hematological病人床边leukoreduction BSLR)接收多个血小板输血。
目的:回顾性分析比较患者血小板输血的时代与BSLR ULR时代。
BSLR集团的材料和方法:患者(409例)和ULR组(586例)比较异源免疫和免疫PTR。临床病理特征,包括性别、怀孕史,暴露输血捐助者,输血,和之前的干细胞移植比较,确定异源免疫的危险因素。
结果:抗体的检出率明显高于ULR相比BSLR组(8.7%比5.4%),以及免疫PTR率(7.3%比3.2%)。多变量分析,女性性别和血小板捐献者暴露的数量,但不普遍leukoreduction或输血期间,被发现的风险因素与同种抗体的形成密切相关。
结论:尽管ULR可能在预防方面优于BSLR non-hemolytic输血反应,发现BSLR ULR一样有效的防止血小板异源免疫和耐火性。因此,BSLR应该积极暗示是一种现实的选择在发展中国家,普遍leukoreduction之前完全实现。