Question

谁能帮我把这篇外文翻译成中文，求高手，高分悬赏

Chemicals. Chemicals were from the following sources:
racemic methamidophos and acephate, Wako Pure Chemical
Industries, Ltd.; S-methyl phosphorodichloridothioate
(3), prepared according to Labkowitz et al. (1974); L-proline
ethyl ester, from treatment of L-proline hydrochloride with
thionyl chloride and ethanol [general procedure of Pate1
and Price (1965)].
Synthesis of Both Enantiomers of Methamidophos
[(+)- and (-)-l]. A solution of L-proline ethyl ester (13
g) in dry pyridine (60 mL) was added dropwise to a cooled
solution of 3 (15 g) in dry benzene (50 mL). Stirring was
continued for 4 h followed by addition of 14 mL of ammonia
water (25%). After being stirred overnight, the
mixture was extracted with ethyl acetate (EtOAc), washed
with HzO, and dried over anhydrous MgS04, and then the
solvent was removed under reduced pressure. The residues
were separated through column chromatography on silica
gel (Wakogel C-200, Wako) by eluting with benzene-ethanol
(95:5) and by subsequent recrystallization (EtOAc)
into diastereomerically pure 4a and 4b. 4a was obtained
(1.32 g) as colorless plates: mp 87 'C; MS, m / z 252 (M'),
J = 7.2 Hz, OCH,CH,), 1.80-2.20 (m, NCH,(CH&C), 2.26
(d,J= 13.4 Hz,SCH,), 3.32 (bs,NH,), 3.37 (m, NCH,CH,),
4.18 (4, J = 7.2 Hz, OCH,CH,), 4.41 (m, NCH(CO0Et)-
CH2). 4b was obtained (0.96 g) as colorless plates: mp 62
205, 179, 70; [&ID -41.1' (C 0.90, CHClJ; NMR 6 1.28 (t,
'C; MS, m / z 252 (M'), 205, 179, 70; [&ID -143' (C 0.63,
CHC13); NMR 6 1.28 (t, J = 7.1 Hz, OCH,CH,), 1.80-2.20
(m, NCH,(CH,),C), 2.29 (d, J = 13.4 Hz, SCH,), 3.45 (bs,
NH2),3 .45 (m, NCH,CH,), 4.18 (9,J = 7.1 Hz, OCH2CH3),
4.28 (m, NCH(COOEt)CH,).
4a (740 mg) was treated with anhydrous
HC1-methanol
(lo%, 10 mL) at room temperature with stirring overnight,
and then most of the methanol was removed under reduced
pressure. The residues were purified through column
chromatography on silica gel (Wakogel C-200) by
eluting with CHC13-methanol (955) to give 120 mg of (+)-1
(29%): mp 68 'C (acetone-EtOAc); [&ID +55.0' (c 0.45,
CHCl,). By the same way, (-)-l was afforded from 4b
(30%): mp 68 'c (acetone-EtOAc); [&ID -53.9' (c 0.36,
Resolution of Both Enantiomers of Acephate [(+)-
and (-)-21. Racemic 2 was resolved with high-performance
liquid chromatography (HPLC; Figure 1) into optically
active (+)-2 [[&ID +64O (c 0.10, CHCl,)] and (-)-2 [[&ID
-62' (c 0.10, CHCl,)]. HPLC was carried out with a
Shimadzu LC-3A liquid chromatograph, and chromatographic
conditions were as follows: column, CHIRALCEL
OC (4.6 X 250 mm, Daicel Chemical Industries, Ltd.);
solvent, hexane-propan-2-01 (4:1), flow rate, 1.0 mL/min;
detection, UV 235 nm.

Answer 1

化学物质。化学物质来自以下方面:
外消旋的甲胺磷和乙酰甲胺磷,Wako纯化学
工业有限公司。;年代甲基phosphorodichloridothioate
(3)、准备根据Labkowitz et al。(1974);l脯氨酸
乙酯,从治疗l脯氨酸盐酸盐与
亚硫酰氯和乙醇(Pate1一般程序等
和价格(1965)]。
两个对映体的合成的甲胺磷
[(+)和(-)- l)。一个解决方案的l脯氨酸乙酯(13
g)在干燥的吡啶(60毫升)添加一滴一滴地到一个冷却
解决方案3(15克)在干燥的苯(50 mL)。搅拌是
持续了4小时后跟添加14毫升的氨
水(25%)。在被搅了一夜之间,
用乙酸乙酯提取液(强弱),水洗
与HzO,在无水MgS04干,然后
溶剂是移除在减压。残留的
通过柱层析法分离对石英吗
凝胶(Wakogel c - 200,Wako)与苯乙醇洗脱
(95:5)和随后的再结晶(强弱)
到diastereomerically纯4 a和4 b。4一个获得
(1.32 g)为无色板块:议员87 ' C、m / z女士,252(m '),
J = 7.2赫兹,哟,CH,),1.80 - -2.20(m,NCH,(CH&C),2.26
(d,J = 13.4赫兹,原理图,),3.32(bs,NH,),3.37(m,NCH,CH,),
4.18(4、J = 7.2赫兹,哟,CH,),4.41(m,NCH(CO0Et)-
CH2)。4 b获得(0.96 g)为无色板块:议员62
205、179、70;[&ID -41.1”(C 0.90,CHClJ;核磁共振6 1.28(t,
“C、m / z女士,252(m)、205、179、70;[-143 &ID(C 0.63,
CHC13);核磁共振6 1.28(t,J = 7.1赫兹,哟,CH,),1.80 - -2.20
(m,NCH,(CH)、C),2.29(d,J = 13.4赫兹,原理图,),3.45(废话,
NH2),3。45(m,NCH,CH,),4.18(9,J = 7.1赫兹,OCH2CH3),
4.28(米,NCH(COOEt)CH,)。
4 a(740毫克)接受无水
盐酸甲醇
(lo %,10毫升)在室温下与搅拌过夜,
然后大部分甲醇是移除在减少
压力。经过纯化的残留物通过列
色谱法在硅胶(Wakogel c - 200)
淋洗与CHC13-methanol(955)提供120毫克的(+)1
(29%):议员68 ' C(丙酮强弱);[&ID + 55.0”(C 0.45,
CHCl,)。通过同样的方式,(-)- l是提供从4 b
(30%):议员68 ' c(丙酮强弱);[&ID -53.9”(c 0.36,
解决两个对映体的乙酰甲胺磷[(+)-
和(-)-21。外消旋2已经解决了高性能
液相色谱法(HPLC;图1)进入光
活跃的(+)2[[&ID + 64 o(c 0.10,CHCl,))和(-)2[[&ID
-62”(c 0.10,CHCl,)]。高效液相色谱法进行
日本岛津公司LC-3A液相色谱仪、色谱
条件如下:列,CHIRALCEL
摄氏度(4.6×250毫米,聚甲醛化学工业有限公司;
溶剂,hexane-propan-2-01(4:1),流量,1.0毫升/分钟;
检测、UV 235海里。