Question

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哺乳动物铁稳态分子机制研究进展

摘要：铁是机体必需微量元素，参与机体合成血红蛋白、肌红蛋白及多种酶的组成和功能发挥，对维持生命和健康至关重要。近四分之一的世界人口遭受铁缺乏或缺铁性贫血的威胁。此外，部分人群还存在铁过载问题，以脏器铁离子蓄积为主要病理改变的遗传性血色病，其在欧美发病率高达1／200，在中国也有报道。血色病后期多诱发肝脏、胰腺及心脏的功能衰退。铁过少或过多对健康都会造成严重危害，机体需要复杂而精密的调控体系维持铁稳态平衡。铁代谢主要包括小肠吸收、肝脏储存、血液转运、巨噬细胞再循环以及周身细胞利用。过去十多年是铁代谢研究的“黄金时期”，先后发现众多铁稳态代谢相关基因。该文综述了近年来哺乳动物铁代谢领域的研究进展，并对铁稳态代谢中存在的问题进行了初步讨论，为理解和进一步深入研究铁代谢分子机制提供参考。

Answer 1

TheResearch Progress of Mammals’ Molecular Mechanism of Iron Homeostasis

Abstract:
Ironis the essential trace element in the body. It involves with the synthesis
of hemoglobin, myohemoglobin, the composition of a variety of enzymes and
function performances; this is of vital importance to the maintenance of life
and health. About one quarter of the world’s population are under the threat of
suffering from iron deficiency and iron deficiency anemia. Moreover，there
are also problems of too much iron in the body. For example, hereditary hemochromatosis which is mainly caused by pathological changes due to high ferric ion accumulation in visceral
organs, the morbidity rate is as high as 1/200 in Europe and Americas, even in China
there were reports of this disease. At the later stages of hemochromatosis, it
usually induces hypofunction of the liver, pancreas and the heart. Too little or
too much iron can caused serious harm to health, the body needs a complex and
sophisticated control system to maintain the balance of iron homeostasis. The
metabolism of iron mainly includes intestinal absorption, liver storage, blood
transferring, macrophage recycling and body cell utilization. Over the past
decade or so, it has been the “golden age” of research on the metabolism of
iron and many genes related to the metabolism of iron homeostasis were
successively discovered. This paper summarizes the progress of researches in
the field of iron metabolism in mammals for the past few years, and conducts a preliminary
discussion on the existing problems of iron homeostasis metabolism, so as to provide
reference for the understanding and further in-depth researches on the molecular
mechanism of iron metabolism.

【英语牛人团】

Answer 2

Research progress in molecular mechanism of iron homeostasis for mammals
Abstract:
Iron is an essential trace element, which acts in composing the hemoglobin and myoglobin, forming various enzymes and performing the functions of the organism, is essential in maintaining the life and health. Nearly 1/4 of the world's population is being threatened by iron deficiency or iron deficiency anemia. Nevertheless, there are also certain groups are overloaded with iron, especially the hereditary hemochromatosis with the main pathological change of accumulation of ferri ion in organs, with a incidence rate reaches as high as 1/200 in Europe and America, and occasional reports in China. Anaphasic hemochromatosis may bring out hypofunctions of liver, pancreas and heart. Both deficiency and nimiety of iron may bring serious harm to health. The organism/body needs a complex and precise regulation system to maintain the balance of iron homeostasis. Iron metabolism including intestinal absorption, liver storage, blood transfer, macrophage recirculation and whole-body cells usage. The previous 10 years is the "golden age" for study of iron metabolism in which many genes related with iron homeostasis metabolism were found. This paper reviewed the research progress in recent years in the field of iron metabolism for mammals, tentatively discussed the problems existing in iron homeostasis metabolism, and provided a reference for understanding and further research of the molecular mechanism of iron metabolism.