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Getty Images It’s shortly after 10 a.m., and The Body—all 237 pounds of him—is in his cubicle, sifting through e-mails. I’m wedged next to his liver, sifting through the metabolic remains of his morning drink: Vitaminwater. It calls itself a “nutrient enhanced” beverage, a nutritious cocktail. Ha! It’s mostly sugar in a bottle, and I love it. It sneaks past the digestive system and lands in the liver, which converts it to fat and sends it straight to me. What a bonanza!
It’s a great time for me and my brethren fat cells. After millennia of toeing the line and giving up our stores whenever the muscles and nerves called on us, we’re now taking over. You don’t have to take my word for it. You can see it on the streets every day. More than 35 percent of adult Americans are obese. Not just overweight—obese. Cardiovascular disease? Type 2 diabetes? Cancer? Not my problem. I’m livin’ large.By 11 a.m.,The Body’s starving. That muffin he had for breakfast provided plenty of calories, but they don’t satisfy him the way they used to. See, it’s my job to send a hormone signal—called leptin—to the brain so it makes The Body feel full. It used to work like a charm. But these days, I pump leptin like it’s a Middle Eastern oil well, and it just floats around in the bloodstream, aimless. With all that excess insulin swirling around to help The Body sop up his extra sugar intake, the brain doesn’t receive my usual leptin signal and issue the “you’re stuffed, stop eating” message. So he’s more apt to feel hungry soon after he finishes eating.Life is sweet—saccharine, really. But it wasn’t always. I remember 40 years ago (The Body was barely a teenager) when I was born along with many of my fatty friends (puberty, the school nurse called it, which is when most adult fat cells should finish forming). I’d wait all day for some spare fatty acids I could store. Back then, most of the nutrition got used up. We fat cells would swell slightly, then shrink again. Those were lean times.But I’m not going anywhere. I mean that literally. Fat cells never disappear. We’re virtually indestructible. The Body can deprive me of the greasy good stuff, and I’ll wither—but when he hits the drive-through again, I’ll rebound faster than he can say “Supersize me!” In a normal body, fat cells are mostly done forming after puberty. But if you’re obese, your fat cells plump up so much that new ones can be created. And lately, my neighborhood’s been getting a little crowded. Every time a fellow fat cell fills up and hits its maximum storage capacity, a new fat cell pops up next door. I’ve heard that a normal body has around 40 billion fat cells, but The Body rolls deep—in here, there are 80 billion just like me!I’m pretty lucky. Back when The Body went off to college, he developed a soda habit. At almost every lunch, he’d knock one back. It was a special treat, and I’d snag a few fat droplets from the liver each time and store them up. He liked the caffeine, too, the pep it gave him in the afternoon. Soon enough, after The Body graduated and found a job, he needed another can of soda just to push through the midafternoon slump. That was the start of my glory years.
Nephron via Wikimedia Commons Hear that? The Body’s opening a can of soda as he digs in to his low-fat microwave lasagna. He’s trying to cut back, shed a few pounds—and hey, if you’re trying to lose weight, it makes sense to eat less fat. But have you ever tried lasagna without butter or oil? Tastes like cardboard. So there’s extra salt and sugar to compensate, and it’s still easy for me to convert some of that sugar to fat and squirrel it away. He has no idea!The poor sap. Back in college, when The Body skied or cycled almost every weekend, his weight was under control. His diet had a lot less sugar, and his brain listened to my leptin warnings, quashing his hunger whenever I managed to plump up. I’d get a little ahead after a big weekend of beer and wings, inflate a tad. Then the next day he’d eat a bagel and apple for breakfast and jump on his bike. His muscles burned up all the handy glucose, and I’d be forced to break down some of my precious self into fatty acids and glycerol. I’d give glycerol to the liver, which would convert it into glucose to burn, and the fatty acids would go straight to the muscles for energy. I’d deflate and hunker down, waiting for his next binge.Now he polishes off the lasagna tray in six bites and swivels back to his computer, clicking and clacking through the afternoon. When he heaves himself from his chair to head home at 5 p.m., it’s the hardest his heart has had to work all day. I’m not worried, though—there’s plenty of fuel in his muscles to provide energy, so I never have to offer up any of myself to help. I’m lying low, laughing, confident I’ll never be called on to liquidate my stash.I get to relax during the hour-long commute home. What will I have for dinner tonight? Fried chicken? Burgers? But when The Body sags into his chair at the dinner table, he sees grilled chicken and salad. Lettuce, tomatoes, peppers… and what the heck is that, toasted pine nuts?! Oil-and-vinegar dressing, not even creamy ranch. Unfortunately, the salad’s fiber slows his digestion of the sugary dinner roll he snags from the basket. What gives? he asks. We’re eating healthy, says his wife. No more junk for dinner.This could be bad for me, but I know The Body, and true to form, he cracks a beer. Sweet relief! I can score fat out of a beer as well as a can of soda. The ethanol it contains is a derivative of sugar, so some of the boozy goodness goes through the liver and converts to fat. After dinner, he takes the dog out for a walk. Thankfully, a casual stroll won’t exert enough energy to dip into my storage. Even better, when he gets home, he plops down to watch the game. Conditioned to snack at night, he grabs a Rice Krispies square, a tiny sugar boost for me. He slides into bed around midnight, hoping for his usual six hours of sleep. While The Body snoozes, I get to relax too. He doesn’t rely on my stores during the middle of the night, so I’m waiting for morning and already pulsating. I know his lack of sleep will make him stressed, hungry, and more likely to crave sugary, high-carb foods. Mmm, maybe doughnuts for breakfast?
It’s a great time for me and my brethren fat cells. After millennia of toeing the line and giving up our stores whenever the muscles and nerves called on us, we’re now taking over. You don’t have to take my word for it. You can see it on the streets every day. More than 35 percent of adult Americans are obese. Not just overweight—obese. Cardiovascular disease? Type 2 diabetes? Cancer? Not my problem. I’m livin’ large.By 11 a.m.,The Body’s starving. That muffin he had for breakfast provided plenty of calories, but they don’t satisfy him the way they used to. See, it’s my job to send a hormone signal—called leptin—to the brain so it makes The Body feel full. It used to work like a charm. But these days, I pump leptin like it’s a Middle Eastern oil well, and it just floats around in the bloodstream, aimless. With all that excess insulin swirling around to help The Body sop up his extra sugar intake, the brain doesn’t receive my usual leptin signal and issue the “you’re stuffed, stop eating” message. So he’s more apt to feel hungry soon after he finishes eating.Life is sweet—saccharine, really. But it wasn’t always. I remember 40 years ago (The Body was barely a teenager) when I was born along with many of my fatty friends (puberty, the school nurse called it, which is when most adult fat cells should finish forming). I’d wait all day for some spare fatty acids I could store. Back then, most of the nutrition got used up. We fat cells would swell slightly, then shrink again. Those were lean times.But I’m not going anywhere. I mean that literally. Fat cells never disappear. We’re virtually indestructible. The Body can deprive me of the greasy good stuff, and I’ll wither—but when he hits the drive-through again, I’ll rebound faster than he can say “Supersize me!” In a normal body, fat cells are mostly done forming after puberty. But if you’re obese, your fat cells plump up so much that new ones can be created. And lately, my neighborhood’s been getting a little crowded. Every time a fellow fat cell fills up and hits its maximum storage capacity, a new fat cell pops up next door. I’ve heard that a normal body has around 40 billion fat cells, but The Body rolls deep—in here, there are 80 billion just like me!I’m pretty lucky. Back when The Body went off to college, he developed a soda habit. At almost every lunch, he’d knock one back. It was a special treat, and I’d snag a few fat droplets from the liver each time and store them up. He liked the caffeine, too, the pep it gave him in the afternoon. Soon enough, after The Body graduated and found a job, he needed another can of soda just to push through the midafternoon slump. That was the start of my glory years.
Nephron via Wikimedia Commons Hear that? The Body’s opening a can of soda as he digs in to his low-fat microwave lasagna. He’s trying to cut back, shed a few pounds—and hey, if you’re trying to lose weight, it makes sense to eat less fat. But have you ever tried lasagna without butter or oil? Tastes like cardboard. So there’s extra salt and sugar to compensate, and it’s still easy for me to convert some of that sugar to fat and squirrel it away. He has no idea!The poor sap. Back in college, when The Body skied or cycled almost every weekend, his weight was under control. His diet had a lot less sugar, and his brain listened to my leptin warnings, quashing his hunger whenever I managed to plump up. I’d get a little ahead after a big weekend of beer and wings, inflate a tad. Then the next day he’d eat a bagel and apple for breakfast and jump on his bike. His muscles burned up all the handy glucose, and I’d be forced to break down some of my precious self into fatty acids and glycerol. I’d give glycerol to the liver, which would convert it into glucose to burn, and the fatty acids would go straight to the muscles for energy. I’d deflate and hunker down, waiting for his next binge.Now he polishes off the lasagna tray in six bites and swivels back to his computer, clicking and clacking through the afternoon. When he heaves himself from his chair to head home at 5 p.m., it’s the hardest his heart has had to work all day. I’m not worried, though—there’s plenty of fuel in his muscles to provide energy, so I never have to offer up any of myself to help. I’m lying low, laughing, confident I’ll never be called on to liquidate my stash.I get to relax during the hour-long commute home. What will I have for dinner tonight? Fried chicken? Burgers? But when The Body sags into his chair at the dinner table, he sees grilled chicken and salad. Lettuce, tomatoes, peppers… and what the heck is that, toasted pine nuts?! Oil-and-vinegar dressing, not even creamy ranch. Unfortunately, the salad’s fiber slows his digestion of the sugary dinner roll he snags from the basket. What gives? he asks. We’re eating healthy, says his wife. No more junk for dinner.This could be bad for me, but I know The Body, and true to form, he cracks a beer. Sweet relief! I can score fat out of a beer as well as a can of soda. The ethanol it contains is a derivative of sugar, so some of the boozy goodness goes through the liver and converts to fat. After dinner, he takes the dog out for a walk. Thankfully, a casual stroll won’t exert enough energy to dip into my storage. Even better, when he gets home, he plops down to watch the game. Conditioned to snack at night, he grabs a Rice Krispies square, a tiny sugar boost for me. He slides into bed around midnight, hoping for his usual six hours of sleep. While The Body snoozes, I get to relax too. He doesn’t rely on my stores during the middle of the night, so I’m waiting for morning and already pulsating. I know his lack of sleep will make him stressed, hungry, and more likely to crave sugary, high-carb foods. Mmm, maybe doughnuts for breakfast?
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Old soldiers never die
friendly aspect of a peaceful lake. Our line of defense is a natural one and can be maintained with a minimum of military effort and expense. It envisions no attack against anyone, nor does it provide the bastions essential for offensive operations, but properly maintained, would be an invincible defense against aggression. The holding of this literal defense line in the western Pacific is entirely dependent upon holding all segments thereof; for any major breach of that line by an unfriendly power would render vulnerable to determined attack every other major segment.
This is a military estimate as to which I have yet to find a military leader who will take exception. For that reason, I have strongly recommended in the past, as a matter of military urgency, that under no circumstances must Formosa fall under Communist control. Such an eventuality would at once threaten the freedom of the Philippines and the loss of Japan and might well force our western frontier back to the coast of California, Oregon and Washington.
To understand the changes which now appear upon the Chinese mainland, one must understand the changes in Chinese character and culture over the past 50 years. China, up to 50 years ago, was completely non-homogenous, being compartmented into groups divided against each other. The war-making tendency was almost non-existent, as they still followed the tenets of the Confucian ideal of pacifist culture. At the turn of the century, under the regime of Chang Tso Lin, efforts toward greater homogeneity produced the start of a nationalist urge. This was further and more successfully developed under the leadership of Chiang Kai-Shek, but has been bromally cautioned as follows:
"Men since the beginning of time have
sought peace. Various methods through the
aystem,
Armageddon will be at our door. The
problem basically is theological and
involves a spiritual recrudescence and
improvement of human character that will
synchronize with our almost matchless=ustified that means, where appeasement has led to more than a sham peace. Like blackmail, it lays the basis for new and successively greater demands until, as in blackmail, violence becomes the only other alternative.
"Why," my soldiers asked of me, "surrender military advantages to an enemy in the field?" I could not answer.
Some may say: to avoid spread of the conflict into an all-out war with China; others, to avoid territorial limits. It condemns that nation, which it is our purpose to save, to suffer the devastating impact of full naval and air bombardment while the enemy's sanctuaries =barrack
friendly aspect of a peaceful lake. Our line of defense is a natural one and can be maintained with a minimum of military effort and expense. It envisions no attack against anyone, nor does it provide the bastions essential for offensive operations, but properly maintained, would be an invincible defense against aggression. The holding of this literal defense line in the western Pacific is entirely dependent upon holding all segments thereof; for any major breach of that line by an unfriendly power would render vulnerable to determined attack every other major segment.
This is a military estimate as to which I have yet to find a military leader who will take exception. For that reason, I have strongly recommended in the past, as a matter of military urgency, that under no circumstances must Formosa fall under Communist control. Such an eventuality would at once threaten the freedom of the Philippines and the loss of Japan and might well force our western frontier back to the coast of California, Oregon and Washington.
To understand the changes which now appear upon the Chinese mainland, one must understand the changes in Chinese character and culture over the past 50 years. China, up to 50 years ago, was completely non-homogenous, being compartmented into groups divided against each other. The war-making tendency was almost non-existent, as they still followed the tenets of the Confucian ideal of pacifist culture. At the turn of the century, under the regime of Chang Tso Lin, efforts toward greater homogeneity produced the start of a nationalist urge. This was further and more successfully developed under the leadership of Chiang Kai-Shek, but has been bromally cautioned as follows:
"Men since the beginning of time have
sought peace. Various methods through the
aystem,
Armageddon will be at our door. The
problem basically is theological and
involves a spiritual recrudescence and
improvement of human character that will
synchronize with our almost matchless=ustified that means, where appeasement has led to more than a sham peace. Like blackmail, it lays the basis for new and successively greater demands until, as in blackmail, violence becomes the only other alternative.
"Why," my soldiers asked of me, "surrender military advantages to an enemy in the field?" I could not answer.
Some may say: to avoid spread of the conflict into an all-out war with China; others, to avoid territorial limits. It condemns that nation, which it is our purpose to save, to suffer the devastating impact of full naval and air bombardment while the enemy's sanctuaries =barrack
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奥巴马全胜英文演讲
Thank you so much.
Tonight, more than 200 years after a former colony won the right to determine its own destiny, the task of perfecting our union moves forward.
It moves forward because of you. It moves forward because you reaffirmed the spirit that has triumphed over war and depression, the spirit that has lifted this country from the depths of despair to the great heights of hope, the belief that while each of us will pursue our own individual dreams, we are an American family and we rise or fall together as one nation and as one people.
Tonight, in this election, you, the American people, reminded us that while our road has been hard, while our journey has been long, we have picked ourselves up, we have fought our way back, and we know in our hearts that for the United States of America the best is yet to come.
I want to thank every American who participated in this election, whether you voted for the very first time or waited in line for a very long time. By the way, we have to fix that. Whether you pounded the pavement or picked up the phone, whether you held an Obama sign or a Romney sign, you made your voice heard and you made a difference.
I just spoke with Gov. Romney and I congratulated him and Paul Ryan on a hard-fought campaign. We may have battled fiercely, but it's only because we love this country deeply and we care so strongly about its future. From George to Lenore to their son Mitt, the Romney family has chosen to give back to America through public service and that is the legacy that we honor and applaud tonight. In the weeks ahead, I also look forward to sitting down with Gov. Romney to talk about where we can work together to move this country forward.
I want to thank my friend and partner of the last four years, America's happy warrior, the best vice president anybody could ever hope for, Joe Biden.
And I wouldn't be the man I am today without the woman who agreed to marry me 20 years ago.Let me say this publicly: Michelle, I have never loved you more. I have never been prouder to watch the rest of America fall in love with you, too, as our nation's first lady. Sasha and Malia, before our very eyes you're growing up to become two strong, smart beautiful young women,just like your mom. And I'm so proud of you guys. But I will say that for now one dog's probably enough.
Thank you so much.
Tonight, more than 200 years after a former colony won the right to determine its own destiny, the task of perfecting our union moves forward.
It moves forward because of you. It moves forward because you reaffirmed the spirit that has triumphed over war and depression, the spirit that has lifted this country from the depths of despair to the great heights of hope, the belief that while each of us will pursue our own individual dreams, we are an American family and we rise or fall together as one nation and as one people.
Tonight, in this election, you, the American people, reminded us that while our road has been hard, while our journey has been long, we have picked ourselves up, we have fought our way back, and we know in our hearts that for the United States of America the best is yet to come.
I want to thank every American who participated in this election, whether you voted for the very first time or waited in line for a very long time. By the way, we have to fix that. Whether you pounded the pavement or picked up the phone, whether you held an Obama sign or a Romney sign, you made your voice heard and you made a difference.
I just spoke with Gov. Romney and I congratulated him and Paul Ryan on a hard-fought campaign. We may have battled fiercely, but it's only because we love this country deeply and we care so strongly about its future. From George to Lenore to their son Mitt, the Romney family has chosen to give back to America through public service and that is the legacy that we honor and applaud tonight. In the weeks ahead, I also look forward to sitting down with Gov. Romney to talk about where we can work together to move this country forward.
I want to thank my friend and partner of the last four years, America's happy warrior, the best vice president anybody could ever hope for, Joe Biden.
And I wouldn't be the man I am today without the woman who agreed to marry me 20 years ago.Let me say this publicly: Michelle, I have never loved you more. I have never been prouder to watch the rest of America fall in love with you, too, as our nation's first lady. Sasha and Malia, before our very eyes you're growing up to become two strong, smart beautiful young women,just like your mom. And I'm so proud of you guys. But I will say that for now one dog's probably enough.
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