Question

He is my father. 否定句（Negative)/ 疑问句 (Question)怎么变？

含有be 动词的任何句子, 变否定句就是在be 动词后面加not；变一般疑问句就把be 动词提到句子的前面.
He is my father. → 否定句（Negative)： He is not my father. → 疑问句 (Question): Is he my father?

Answer 1

句子中有be动词，变否定句时直接在be后面加not,一般疑问句时直接把be动词提到句子开头
即

He isn't my father.

Is he your father?

Answer 2

否定句：He is not my father
疑问句：Is he my father？

Answer 3

He isn't my father.
Is he your father?
Whose father is he?