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已死亡的22例患者中死于脑部病变复发比例为22.7%(5/22),低于文献所报道的单纯全脑放疗野内复发率[6],说明适形放疗推量对于提高脑部病灶的局控率明显有效。而多数患...
已死亡的22例患者中死于脑部病变复发比例为22.7%(5/22),低于文献所报道的单纯全脑放疗野内复发率[6],说明适形放疗推量对于提高脑部病灶的局控率明显有效。而多数患者(16/22)是死于原发灶未控或复发及其它脏器转移,提示对于脑转移瘤患者,为了更长地延长生存期,应采取有效的综合治疗措施。死亡患者中位生存期为9.3个月,疗效好于单纯全脑放疗的3~6个月生存期[4],有延长生存期的趋势。但长期疗效有待进一步观察。
脑转移瘤放疗常见的并发症是急性放射性脑水肿,多在放疗开始的1~2周内出现。在配合脑部适形放疗后,转移病灶剂量可以增加至60Gy以上,但对周围正常组织并无太大影响。且本组33例患者在放疗开始时即予脱水处理,故放射性脑水肿的发生率仅为9%,程度较轻,经脱水治疗后很快缓解,说明适形放疗并不明显增加放疗毒副反应。
本研究显示,三维适形放疗配合全脑照射脑转移瘤能安全有效地控制脑转移病灶,缓解神经症状和体征,改善生活质量,并有延长生存期的趋势,疗效优于常规治疗。
Has died in 22 example patients dies in the brain pathological change recrudescence proportion is 22.7%(5/22), is lower than pure entire brain radiotherapy wild in recurrence rate [6] which the literature reported that explained that the suitable shape radiotherapy pushes the quantity regarding to enhance brain infection's bureau controlling rate obviously effective. But the most patients (16/22) is dies in the primary stove has not controlled or the recrudescence and other internal organs shifts, prompts shifts the lump patient regarding the brain, for longer lengthens the lifetime, should take the effective complex therapy measure. In the death patient the position lifetime is 9.3 months, the curative effect good in pure entire brain radiotherapy 3~6 month lifetime [4], has the extension lifetime tendency. But the long-term curative effect waits for further observing.
The brain shifts the lump radiotherapy common complication is the acute radioactive hydro-cephalus, many appears in 1~2 weeks which the radiotherapy starts. After coordinating the brain suitable shape radiotherapy, shifts the infection dosage to be possible to increase to 60Gy above, but does not have to the periphery Normal tissue affects too greatly. And this group of 33 example patient when the radiotherapy starts namely gives dehydrated processing, therefore the radioactive hydro-cephalus's formation rate is only 9%, the degree is light, after dehydrated treatment the very quick alleviation, showed that the suitable shape radiotherapy increases the radiotherapy poisonous side reaction not obviously.
This research demonstrated that the three dimensional suitable shape radiotherapy coordinates the entire brain illumination brain to shift the lump to be able to control the brain to shift the infection effectively safely, the alleviation nerve symptom and the symptom, the improvement quality of life, and has the extension lifetime tendency, the curative effect surpasses the conventional treatment. 展开
脑转移瘤放疗常见的并发症是急性放射性脑水肿,多在放疗开始的1~2周内出现。在配合脑部适形放疗后,转移病灶剂量可以增加至60Gy以上,但对周围正常组织并无太大影响。且本组33例患者在放疗开始时即予脱水处理,故放射性脑水肿的发生率仅为9%,程度较轻,经脱水治疗后很快缓解,说明适形放疗并不明显增加放疗毒副反应。
本研究显示,三维适形放疗配合全脑照射脑转移瘤能安全有效地控制脑转移病灶,缓解神经症状和体征,改善生活质量,并有延长生存期的趋势,疗效优于常规治疗。
Has died in 22 example patients dies in the brain pathological change recrudescence proportion is 22.7%(5/22), is lower than pure entire brain radiotherapy wild in recurrence rate [6] which the literature reported that explained that the suitable shape radiotherapy pushes the quantity regarding to enhance brain infection's bureau controlling rate obviously effective. But the most patients (16/22) is dies in the primary stove has not controlled or the recrudescence and other internal organs shifts, prompts shifts the lump patient regarding the brain, for longer lengthens the lifetime, should take the effective complex therapy measure. In the death patient the position lifetime is 9.3 months, the curative effect good in pure entire brain radiotherapy 3~6 month lifetime [4], has the extension lifetime tendency. But the long-term curative effect waits for further observing.
The brain shifts the lump radiotherapy common complication is the acute radioactive hydro-cephalus, many appears in 1~2 weeks which the radiotherapy starts. After coordinating the brain suitable shape radiotherapy, shifts the infection dosage to be possible to increase to 60Gy above, but does not have to the periphery Normal tissue affects too greatly. And this group of 33 example patient when the radiotherapy starts namely gives dehydrated processing, therefore the radioactive hydro-cephalus's formation rate is only 9%, the degree is light, after dehydrated treatment the very quick alleviation, showed that the suitable shape radiotherapy increases the radiotherapy poisonous side reaction not obviously.
This research demonstrated that the three dimensional suitable shape radiotherapy coordinates the entire brain illumination brain to shift the lump to be able to control the brain to shift the infection effectively safely, the alleviation nerve symptom and the symptom, the improvement quality of life, and has the extension lifetime tendency, the curative effect surpasses the conventional treatment. 展开
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