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仙连颗粒对激素依赖型ITP骨髓TPO、TGF-β1
水平的影响及临床研究

摘 要
目的：本研究所用采用的方剂仙连颗粒，系导师行医多年，经十余年悉心理论研究和临床经验总结所创。通过研究仙连颗粒对骨髓微环境中调节巨核细胞发育的正性因子血小板生成素( TPO) 与负性作用因子转化生长因子β1 ( TGF-β1 )水平变化的影响，以评价仙连颗粒对激素依赖型ITP的治疗效果及其作用机制，为临床应用提供更多依据。
方法：选取符合诊断标准的病例64例，按1:1的分配原则，运用单盲法随机分入治疗组与对照组，治疗组32例，给予仙连颗粒（装胶囊，每粒相当于 生药1.5g），每次10粒，一日三次，同时口服强的松片0.5mg/kg/d，待血小板恢复正常后，每两周减5mg，减至维持量5-10mg/d；对照组32例，给予安慰剂（糊精装胶囊），每次10粒，一日三次，同时口服强的松片0.5mg/kg/d，用法同治疗组，均以两个月为一疗程，观察两个疗程。观察两组患者治疗前后的临床症状（紫斑的分布与颜色、皮肤粘膜及内脏出血表现、发热、烦渴、五心烦热、口干、潮热盗汗、神疲乏力、气短以及舌象、脉象等）以及外周血象、骨髓象的改善情况。采用ELISA法测定治疗前后骨髓TPO、TGF-β1水平并与对照组作统计学比较。
结果：治疗后治疗组的有效率、显效率均明显高于对照组。治疗后治疗组在临床症状、血象、骨髓象的改善方面与对照组有非常显著性差异（P<0.01）。与疗前相比，治疗组、对照组均可以降低TPO、TGF-β1水平（P <0.01），但对照组在降低TPO、TGF-β1水平上不如仙连颗粒，进一步研究还发现仙连颗粒治疗阴虚血热型、气虚不摄型疗效较好，血热妄行型疗效较差。
结论：①该制剂能改善激素依赖型ITP患者的临床症状、血象、骨髓象，提示具有升高血小板功效的仙连颗粒在治疗ITP长期疗效方面优于强的松。②实验研究结果显示，该制剂能使血清骨髓TPO、TGF-β1的水平降低。③TPO、TGF-β1可为ITP 患者临床病情判断、预后估计、制定个体性治疗方案提供依据, 在ITP 的病理过程中发挥重要作用。
关键词：激素依赖型；特发性血小板减少性紫癜；仙连颗粒；临床疗效；TPO；TGF-β1
TPO 又称巨核细胞生长衍生因子(Megakaryocyte growth and development factor ,MGDF
转化生长因子(transforming growth factor, TGF-β1) 斑疹 rashes
烦 irritability
烦躁 irritability and restlessness
潮热 tidal fever or afternoon tidal fever
盗汗 night sweats

神疲 weariness

Answer 1

Objective: this study adopts the immortal, even granules prescriptions for the tutor for more than ten years, practicing theoretical research and clinical experience carefully summarize the. Through the study of hone marrow immortal even granules in the environment of the development adjustment of megakaryocytes positive factor (TPO) and platelet function factor into negative growth factor beta 1 (1) level TGF - beta, the influence of variation in evaluation of steroid dependence immortal even particles and the therapeutic effect of ITP mechanism for clinical application, provide more evidence.
Methods: the cases of diagnosis accord with standard, 1 = 64 distribution principle, using the method of stochastic blinded in treatment group and control group points, 32 cases in treatment group and give fairy even particles (outfit capsule, each grain to 1.5 g), each time out 10, three times a day, and oral prednisone slice 0.5 mg/kg/d, platelet after returning to normal, every two weeks, and to maintain 5mg reduce quantity of 10mg/d; 5 - 32 cases of control group, and placebo (dextrin outfit, 10) time capsules, three times a day, and oral prednisone slice 0.5 mg/kg/d, usage in treatment group, with two months for a period, two sessions. Two groups of patients and observed the clinical symptoms (the distribution and the color purple porphyry, skin mucous membrane and internal bleeding, fever, thirst, and five hot, dry mouth, hot night sweats, shortness of breath and tongue, etc) and peripheral pulses, bone marrow as. Before and after treatment were adopted ELISA, TGF - beta marrow TPO 1 level for statistical comparison group and control group.
Results: after treatment, the effective treatment group and control group were significantly higher efficiency. The treatment group adopted in the clinical symptoms, the improvement of bone marrow feature, with very significant difference (P < 0.01). Compared with before, healing in treatment group and control group can reduce TPO, TGF - beta 1 (P < 0.01), but in TGF, reduce TPO group 1 level as a beta - even granules, further studies celestial fairy also found that even XieReXing Yin deficiency, the treatment effect is not taken type heat, blood type folly.
Conclusions: (1) the preparations can improve hormone dependence of clinical symptoms and ITP adopted, bone marrow, has increased as the platelet function even granule in treatment of ITP long-term efficacy excels prednisone. Experimental results showed that (the preparations can make serum bone marrow TPO, TGF - beta 1 level. 3-1, TGF TPO beta for patients with clinical condition judgment, ITP and prognosis for individual treatments to provide basis for the pathological process in ITP play an important role.
Keywords: steroid dependence, Idiopathic thrombocytopenic purpura, Fairy even particles, Clinical curative effect, TPO, TGF - beta 1

Answer 2

小妹妹，说实话给10分估计是没有人会帮忙真正人工翻译的，去下个灵格斯翻译家，什么都搞定，我的毕业设计就是靠它混过去的,写吗15000字汉字，3000字翻译是吧 。

Answer 3

要找那种比较擅长医药翻译的 一般人翻译不了啊

Answer 4

这些翻译起来也不难，但是你怎么这么懒呢，我也懒的给你翻