Question

医学文献翻译，悬赏100分，急！！

Each of these GRFS components is clinically meaningful. GRFS therefore represents ideal recovery from HCT (at 1 year) and a measure of cure without ongoingmorbidity. Using a cohort of 628 adult patients treated with tacrolimus (Tac) and methotrexate (MTX) as GVHD prophylaxis
between 2006 and 2009, data from the Center for International Blood
and Marrow Transplant Research determined that the 1-year probabil-
ity of GRFSwas 23%(95%confidence interval [CI] 20-26).5 Thus,
only approximately one-quarter of adult patients transplanted for ma-
lignant disease survived without at least 1 of thesemajor complications
during the first 12 months after HCT. To better understand which
factors influence GRFS for both pediatric and adult patients, we
studied the individual events that composeGRFS and determined the
overall GRFS in a large cohort of patients treated with uniform sup-
portive care at our institution. In doingso,wesoughttoidentifymod-
ifiable characteristics that could help optimize patients’ outcomes.

Answer 1

这些组件是有临床意义的起。因此，从理想的恢复起代表HCT（1年）和一个测量不ongoingmorbidity治愈。使用一个队列的628名成年患者的他克莫司（TAC）和氨甲喋呤（MTX）GVHD的预防
2006和2009之间，从国际血液中心数据
和骨髓移植研究确定一年的概率—
而grfswas 23%（95%可信区间[CI] CONfi20-26）。5因此，
只有约四分之一的成人患者移植的马—
恶性疾病中幸存下来，没有至少1的这些主要的并发症
在fiHCT后前12个月。为了更好的理解
为儿童和成人患者的影响因素fl起，我们
研究了个别事件，composegrfs确定
在一个大的一致支持治疗的患者队列的整体起—
发生率在我院护理。在这样做时，wesoughttoidentifymod—
我fi能的特性，可以帮助优化患者的治疗效果。