Question

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Tuberculosis Prevention in Mexican ImmigrantsLimitations of Short-Course Therapy

Namratha R. Kandula, MD, MPH, Mark S. Dworkin, MD, MHTPM, Margaret R. Carroll, RN, BS,Diane S. Lauderdale, PhD

Background: Two months of rifampin and pyrazinamide (RIF/PZA) for tuberculosis prevention ha been advocated as a way to improve adherence in mobile populations, such as recen immigrants. However, RIF/PZA requires intensive patient and laboratory monitoring for hepatotoxicity.

Objectives: To describe the feasibility and outcomes of using RIF/PZA for TB prevention during a tuberculosis outbreak in a Mexican immigrant community, where 23 adults and 11 children were treated with RIF/PZA between August 2001 and October 2001.

Methods: Retrospective chart review and interviews with health department employees were conducted to assess completion rates, hepatotoxicity, cost, and feasibility of monitoring.

Results: Ten (91%) children and 13 (57%) adults completed RIF/PZA. One child (9%) and four adults (17%) developed drug-induced hepatitis. Cultural barriers affected care. The adult resisted the biweekly blood draw, believing it would “drain them of energy.” RIF/PZA, plumonitoring, was twice as costly as 4 months of rifampin.
Conclusions: RIF/PZA was associated with significant hepatotoxicity, poor completion, and cultura barriers to monitoring, and was more costly than standard therapy. Tuberculosis prevention must address potential clinical, cultural, and economic barriers to completion and monitoring of short-course therapy in immigrants.
(Am J Prev Med 2004;26(2):163–166) © 2004 American Journal of Preventive Medicine

Answer 1

翻译：
Tuberculosis Prevention in Mexican ImmigrantsLimitations of Short-Course Therapy
墨西哥移民结核病防治的短期疗法的局限性
Namratha R. Kandula, MD, MPH, Mark S. Dworkin, MD, MHTPM, Margaret R. Carroll, RN, BS,Diane S. Lauderdale, PhD
这些是作者名字，不翻译了，自己音译吧
Background: Two months of rifampin and pyrazinamide (RIF/PZA) for tuberculosis prevention ha been advocated as a way to improve adherence in mobile populations, such as recen immigrants. However, RIF/PZA requires intensive patient and laboratory monitoring for hepatotoxicity.
背景：使用为期2个月的利福平和吡嗪酰胺 (RIF/PZA)作为结核病的防治方法已经被当成一种提高流动人口（比如移民）的凝聚力的方式。然而 RIF/PZA要求病人要相对集中和对肝脏毒性的实验室观察。
Objectives: To describe the feasibility and outcomes of using RIF/PZA for TB prevention during a tuberculosis outbreak in a Mexican immigrant community, where 23 adults and 11 children were treated with RIF/PZA between August 2001 and October 2001.
目的：为了阐述在墨西哥移民社区结核病爆发期间使用RIF/PZA作为结核病防治措施的可行性与效果，从2001年8月至10月，这个社区的23名成年人和11名小孩接受了RIF/PZA 治疗。
Methods: Retrospective chart review and interviews with health department employees were conducted to assess completion rates, hepatotoxicity, cost, and feasibility of monitoring.
方法：以审核可回顾图表和对卫生部雇员的访问作为对完成率、肝脏毒性、费用和观察的可行性的评价方式。
Results: Ten (91%) children and 13 (57%) adults completed RIF/PZA. One child (9%) and four adults (17%) developed drug-induced hepatitis. Cultural barriers affected care. The adult resisted the biweekly blood draw, believing it would “drain them of energy.” RIF/PZA, plumonitoring, was twice as costly as 4 months of rifampin.
结果：10个儿童（91%）和13个成人（57%）完成了RIF/PZA，一个儿童（9%）和4个成人（17%）产生了药物性肝炎。文化障碍影响到了治疗效果。成年人抵触2个星期一次的血液抽查，因为他们认为这会“吸干他们的活力”。在无监察的情况下，使用RIF/PZA的费用相当于利福平4个月用药的费用。
Conclusions: RIF/PZA was associated with significant hepatotoxicity, poor completion, and cultura barriers to monitoring, and was more costly than standard therapy. Tuberculosis prevention must address potential clinical, cultural, and economic barriers to completion and monitoring of short-course therapy in immigrants.
结论：RIF/PZA具有显著的肝脏毒性，低治疗性，受文化障碍的影响而难以监察，并且比标准的治疗方法费用更高。结核病防治应致力于可行的临床的、无文化障碍和更经济的方式来实现对移民们短期治疗的监察与效果。
(Am J Prev Med 2004;26(2):163–166) © 2004 American Journal of Preventive Medicine
美国预防医学杂志(Am J Prev Med 2004;26(2):163–166) © 2004

手工翻译的，希望对你有帮助！不是专业的，请参考！

Answer 2

在结核病防治短池墨西哥ImmigrantsLimitations治疗

Namratha河Kandula，医学博士，公共卫生硕士，马克德沃金学，医学博士，MHTPM，玛格丽特河卡罗尔，护士，英国BS，劳德代尔黛安学博士

背景：两个利福平和吡嗪酰胺结核预防公顷（RIF的/ PZA）个月，一直主张，以此来提高移动人群，如recen移民，坚持。不过，间质纤维化/ PZA需要深入病人的肝和实验室监测。

目的：描述的可行性和使用过程中预防结核病在墨西哥移民社区，其中23名成人和1​​1名儿童分别与间质纤维化/ PZA治疗2001年8月至2001年10月RIF的结核病疫情/ PZA成果。

方法：回顾图审查，并与卫生部门的员工进行了采访，以评估完成率，肝，成本和监测的可行性。

结果：10例（91％）的儿童和13（57％）完成成人间质纤维化/ PZA。一个孩子（9％）和四个成年人（17％）开发的药物性肝炎。文化障碍影响的照顾。成人抵制双周抽血，认为这将“能源消耗它们。”间质纤维化/ PZA，plumonitoring，曾两次到4个月利福平昂贵。
结论：间质纤维化/ PZA是与显着的肝毒性，不良完成和cultura障碍监测，比标准治疗更昂贵。要解决潜在的结核病防治临床，文化和经济障碍完成和短期课程，移民治疗监测。
（上午Ĵ预防医学2004; 26（2）:163 - 166）© 2004年美国预防医学杂志
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