Question

求翻译一段英文

The type I interferons are encoded in series on human
chromosome 9p. Th ere are 13 functional IFNα genes, one
IFNβ gene, one IFNκ gene encoding a protein that is
preferentially expressed in skin, one IFNε gene that is
expressed in placenta and fetal membranes, and one
IFNω gene [24]. All of the protein products of the type I
interferon family bind to a single heterodimeric receptor
composed of IFNAR1 and IFNAR2. Consideration of a
potential pathogenic or protective role for individual type
I interferons, particularly IFNα and IFNβ, involves understanding
the cell types that might preferentially produce
these interferons, the distinct binding properties of IFNα
and IFNβ for the type I interferon receptor (IFNAR), and
whether these interferons engage distinct signaling pathways
and activate distinct target genes.
While classic teaching holds that IFNβ is most eff ectively
produced by fi broblasts and that IFNα is primarily
produced by plasmacytoid dendritic cells, many cell types
can in fact produce both interferons, particularly in the
setting of a viral stimulus [25]. Diff erential production of
one or another type I interferon in diff erent contexts is
probably in part cell-type related but also determined by
the location of those cells [21,23,26,27]. IFNβ is produced
by synoviocytes and keratinocytes, and in small amounts
by monocyte-derived cells. IFNκ, a type I interferon that
has attracted less attention than IFNβ and IFNα, is
apparently predominantly made by keratinocytes, based
on available data [28]. IFNβ-producing cells are located
in tissue linings, and IFNβ can also be produced by
stromal cells through a novel pathway that involves
activation of lymphotoxin-β receptors [29].

Answer 1

我型干扰素是编码人类染色体9P系列。钍ERE 13个职能干扰素α基因，一个IFNβ基因之一IFNκ基因编码的一个优先皮肤中表达的蛋白质，一个IFNε基因，是在胎盘和胎膜表达，和一个IFNω基因[24]。所有的I型干扰素家族IFNAR1和IFNAR2组成一个单一的异二聚体受体结合的蛋白质产品。审议，一个潜在的致病性或个别I型干扰素，特别是IFNα和IFNβ保护作用，需要了解的细胞类型，可能会优先生产这些干扰素，不同的绑定属性IFNα和IFNβI型干扰素受体（IFNAR），这些干扰素是否从事不同的信号通路，并激活不同的的靶基因。虽然经典教学认为IFNβ是大部分EFF ectively高保真broblasts，主要是由浆细胞树突状细胞产生干扰素α，可产生多种细胞类型，其实这两种干扰素，尤其是在设置的一种病毒性刺激[25]。变化erential生产的一个或另一个差异erent上下文I型干扰素可能是部分细胞类型有关，但这些细胞的位置，也决定[21,23,26,27]。 IFNβ是由滑膜细胞和角质形成细胞，以及少量的单核细胞衍生的细胞。 IFNκ，I型干扰素，已吸引不到IFNβ和IFNα注意，显然主要由角质形成细胞，根据现有数据[28]。 IFNβ的细胞是位于组织衬里，IFNβ也可以通过一种新的途径，包括淋巴毒素-β受体激活的基质细胞产生[29]。

追问

!!!!!太猛了 你是自己翻译的还是用什么工具的吗? 大哥

追答

在线

追问

能介绍下吗?我在看英文文献 急需啊~这只是其中一段

追答

灵格斯

Answer 2

在短片（预告片）中，我们可以看到实际上Wilon 说服 House约Cuddy出来，但这位天才并不热衷于这个想法：“她并不是一个在酒吧放荡的女子，而是我工作上的普通上司。”
这周House的患者，是一个被带到Princeton Plainsboro名叫Anna Attanasio的少女。由于在荒野求生了一晚，她的身体严重肿胀。这个女孩并不愿意完全坦诚自己的遭遇及病因，所以House的医疗小队必须在她病情不断恶化的情况下为她作出诊断。但是事情再一次陷入困境，这个女孩子开始出现了幻想症，无法区分现实与幻像。

p.s. 我没有看过这个美剧 可能会有地方翻译理解错误 希望可以帮到你 :D

Answer 3

crazy.......... 楼下的好厉害啊！