Question

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contrast media do not mix well with blood and seem to pass the lung only slowly. Intravenous injection of highly concentrated contrast media may resuLt in lower arterial iodine concentration than the same iodine dose of a less concentrated preparation delivered in the same time.
According to the literature, there is a broad range of optimal contrast medium concentrations between 300 and 370 mg I/mL providing maximal efficacy in CT if injected at the same iodine delivery rate and dose. When intravenous digital subtraction angiograph was introduced, Langer et al. compared iopromide 240, 300, 335, 370 and 400 in a randomized double blind crossover study in 78 patients..13 Lower concentrations were injected slightly faster and at a slightly higher volume to achieve the same iodine dose and iodine deivery rate. This is possible because of the lower viscosity of less concentrated solutions. It is not surprising that very low concentrations are too diluted from
Study design
3 groups of 14-15 patients each
Group I: 100ml,300mgl/ml,4m[/s
Group II:
91 ml, 330 mg l/ml, 3.5 mt/s
Group ML
80 ml, 370 mg l/ml, 3 ml/s
No major difference between concentrations if injected at the same iodine dose and iodine delivery rate (langeret a I., personal communication).
[Figure 4] Maximum contrast enhancement in the aorta following fast intravenous injection of iopromide.
the beginning and require too high injection rates whereas too high concentrations (like honey) are hard to inject, do not mix welL with aqueous media and wash only slowly off the lungs. Concentrations of 300, 335 and 370 were equally effective. This has been confirmed by a study in CT (see figure 4). The results are in agreement with a similar study comparing iohexol 300 and 350 and computer simulation.1*15 When highly concentrated contrast media are injected at higher iodine doses than less concentrated preparations (e.g. at the same volume) or higher iodine delivery rates (i.e. same injection rate as less concentrated preparations), disadvantages of the higher viscosity may not become apparent.1E
译得好有100

Answer 1

相比之下媒体切勿将与血液，似乎只有通过肺缓慢。静脉注射高浓度造影剂可能会导致动脉碘浓度低比相同剂量的碘较少集中交付准备在同一时间。

根据文献，有一个广泛的最佳浓度造影剂300至370毫克的I /毫升提供最大效能的CT如果在同一注射碘交付率和剂量。当静脉数字减影血管造影介绍，兰格等人。相比碘普罗胺240 ， 300 ， 335 ， 370和400中的随机双盲交叉研究78例.. 13注入低浓度稍快和略高量达到同样的碘和碘deivery剂量率。这是因为较低的粘度不太集中的解决方案。毫不奇怪，非常低的浓度稀释到太

研究设计

3组病人每14-15

第一组： 100毫升， 300mgl/ml ， 4分[ /秒

第二组：

九一毫升，升330毫克/毫升， 3.5吨/秒

集团民盟

八十○毫升， 370毫克升/毫升， 3毫升/县没有重大区别浓度如果在同一注射剂量碘和碘分娩率（ langeret 1一，个人交流） 。

[图4 ]最大对比度增强主动脉后快速静脉注射碘普罗胺。

一开始，并要求太高而注射率也高浓度（如蜂蜜）难以注入，不与水混合以及媒体和洗缓慢了肺部。浓度为300 ， 335和370也同样有效。已经证实了这一点在CT的研究（见表4 ） 。结果是一致的一项类似的研究比较，碘海醇300和350和计算机simulation.1 * 15时，高度集中的对比剂注射剂量较高碘比不太集中的筹备工作（例如，在同量）或更高碘交付率（即同样的注射率较集中的筹备工作） ，缺点较高粘度可能不会成为