Question

求一段英文翻译

Genetic association studies are central to efforts to identify and characterise genomic variants underlying
susceptibility to multifactorial disease. However, obtaining robust replication of initial association findings has
proved difficult. Much of this inconsistency can be attributed to inadequacies in study design, implementation, and
interpretation—inadequately powered sample groups are a major concern. Several additional factors affect the
quality of any given association study, with appropriate sample-recruitment strategy, logical variant selection,
minimum genotyping error, relevant data analysis, and valid interpretation all essential to generation of robust
findings. Replication has a vital role in showing that associations that are identified reflect interesting biological
processes rather than methodological quirks. For an unbiased view of the evidence for and against any particular
association, study quality, rather than significance value, needs to play the dominant part.

Answer 1

遗传相关研究中心的努力来识别和表征基因组变异
对多病。然而,得出可靠的复制初始协会发仔尺尘现了
证明是很困难的。许多这样的矛盾可以归结为不足,研究设计,实施
interpretation-inadequately动力的样困誉本组织的一个重大问题。一些附加因素的影响
任何关联研究的质量,以适当的sample-recruitment战略选择,逻辑变种,
最小误差、相关基因重复测量资料的统计分析,有效解释所有必要的鲁棒性
调查的结果。复制有重要作用,表明协会鉴定反映有趣的生物
过程,而不是方法论怪癖。对于一个客观的观点,对任何特定的证据
协念禅会、学习素质,而不是意义的价值,需要发挥主导作用。

Answer 2

遗传关联研究中心的努力，以确姿袜定潜在的基因组变异和定性
多因子疾病的易感性。但是，获取协会的初步调查结果强劲复制
困难重重。这种不一致的大部分可以归因于研究的不足之处设计，实施和
口译供电不足的样本群体是一个大问题。若干其他因素影响
任何给定质量的相关性研究，在适当采样招聘策略，选择合理的变种，
最低分型错误，分析相关数据，并有效的所有必要的解释又一代的强劲
调查结果。复制具有重要作用，显示在已确定反映协稿信会有趣的生物
过程而不是方法怪癖。对于一个不带偏见的观点的迹敬激证据，反对任何特定
协会，研究质量，而不是意义的价值，需要发挥主导的一部分。